Showing studies matching your search17 results shown

Studies (17 shown)

NCT06780137PHASE1, PHASE2RECRUITING

A Study to Evaluate the Safety and Efficacy of Gocatamig (MK-6070) and Ifinatamab Deruxtecan (I-DXd) in Participants With Relapsed/Refractory Extensive-Stage Small Cell Lung Cancer (MK-6070-002)

Sponsor · Merck Sharp & Dohme LLCCondition · Small Cell Lung CancerIntervention · Gocatamig, Ifinatamab Deruxtecan (I-DXd)Updated Apr 2026
NCT05280470PHASE2ACTIVE_NOT_RECRUITING

Ifinatamab Deruxtecan (I-DXd) in Subjects With Pretreated Extensive-Stage Small Cell Lung Cancer (ES-SCLC)

Sponsor · Daiichi SankyoCondition · Extensive-stage Small-cell Lung CancerIntervention · Ifinatamab Deruxtecan (I-DXd)Updated Feb 2026
NCT04145622PHASE1, PHASE2RECRUITING

Study of Ifinatamab Deruxtecan (DS-7300a, I-DXd) in Participants With Advanced Solid Malignant Tumors

Sponsor · Daiichi SankyoCondition · Advanced Solid Tumor, Malignant Solid TumorIntervention · Ifinatamab deruxtecan (I-DXd)Updated May 2026
NCT04471727PHASE1, PHASE2ACTIVE_NOT_RECRUITING

A Study in Participants With Advanced Cancers Associated With Expression of DLL3 (MK-6070-001/HPN328-4001)

Sponsor · Harpoon Therapeutics, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)Condition · Small-Cell Lung Cancer, Neuroendocrine CarcinomaIntervention · Gocatamig, AtezolizumabUpdated Feb 2026
NCT06925737PHASE3RECRUITING

A Clinical Study of Ifinatamab Deruxtecan (I-DXd) in People With Metastatic Prostate Cancer (MK-2400-001)

Sponsor · Merck Sharp & Dohme LLCCondition · Prostate Cancer, Prostatic NeoplasmsIntervention · Ifinatamab deruxtecan, DocetaxelUpdated May 2026
NCT06330064PHASE2RECRUITING

A Study To Evaluate The Efficacy And Safety Of Ifinatamab Deruxtecan (I-DXd) In Subjects With Recurrent Or Metastatic Solid Tumors (IDeate-PanTumor02)

Sponsor · Daiichi SankyoCondition · Recurrent or Metastatic Solid TumorsIntervention · Ifinatamab deruxtecanUpdated Feb 2026
NCT06863272PHASE1, PHASE2RECRUITING

A Clinical Study of Ifinatamab Deruxtecan Based Treatment Combinations or as Monotherapy to Treat Metastatic Castrate Resistant Prostate Cancer (mCRPC) (MK-2400-01A/IDeate-Prostate02)

Sponsor · Merck Sharp & Dohme LLCCondition · Castration-Resistant Prostatic Cancer, MetastasisIntervention · Docetaxel, Ifinatamab DeruxtecanUpdated May 2026
NCT06780085PHASE2RECRUITING

A Study of Investigational Agents in Participants With Previously Treated Stage IV Nonsquamous Non-small Cell Lung Cancer (NSCLC) (MK-3475-01H/KEYMAKER-U01)

Sponsor · Merck Sharp & Dohme LLCCondition · Carcinoma, Non-Small-Cell LungIntervention · Raludotatug Deruxtecan, Ifinatamab DeruxtecanUpdated May 2026
NCT07405151PHASE1, PHASE2RECRUITING

A Clinical Trial of Ifinatamab Deruxtecan in People With Advanced Esophageal Cancer (MK-3475-06F)

Sponsor · Merck Sharp & Dohme LLCCondition · Oesophageal Squamous Cell CarcinomaIntervention · I-DXd, Rescue MedicationUpdated May 2026
NCT07535359AVAILABLE

Medical Access Program for Ifinatamab Deruxtecan in 3L+ Pretreated Extensive-stage Small Cell Lung Cancer

Sponsor · Daiichi SankyoCondition · SCLC, Extensive-stage Small Cell Lung CancerIntervention · Ifinatamab DeruxtecanUpdated May 2026
NCT07227597PHASE1, PHASE2RECRUITING

A Clinical Study of Gocatamig (MK-6070) and Infinatamab Deruxtecan (MK-2400) in People With Small Cell Lung Cancer (MK-6070-003)

Sponsor · Merck Sharp & Dohme LLCCondition · Small Cell Lung Cancer Extensive StageIntervention · Gocatamig, I-DXdUpdated May 2026
NCT06203210PHASE3RECRUITING

A Study of Ifinatamab Deruxtecan Versus Treatment of Physician's Choice in Subjects With Relapsed Small Cell Lung Cancer

Sponsor · Daiichi SankyoCondition · Small Cell Lung CancerIntervention · Ifinatamab deruxtecan, TopotecanUpdated Mar 2026
NCT06362252PHASE1, PHASE2RECRUITING

A Study of I-DXd in Combination With Atezolizumab With or Without Carboplatin as First-Line Induction or Maintenance in Subjects With Extensive Stage-Small Cell Lung Cancer (IDeate-Lung03)

Sponsor · Daiichi SankyoCondition · Extensive Stage-small Cell Lung CancerIntervention · Ifinatamab deruxtecan, AtezolizumabUpdated Feb 2026
NCT06644781PHASE3RECRUITING

A Study of Ifinatamab Deruxtecan in Subjects With Pretreated Advanced or Metastatic Esophageal Squamous Cell Carcinoma (ESCC) (IDeate-Esophageal01)

Sponsor · Daiichi SankyoCondition · Esophageal Squamous Cell CarcinomaIntervention · Ifinatamab deruxtecan, DocetaxelUpdated Jan 2026
NCT06780098PHASE2RECRUITING

Substudy 01I: A Study of Investigational Agents in Participants With Previously Treated Stage IV Squamous Non-small Cell Lung Cancer (NSCLC) (MK-3475-01I/KEYMAKER-U01I)

Sponsor · Merck Sharp & Dohme LLCCondition · Lung NeoplasmIntervention · R-DXD, I-DXDUpdated May 2026
NCT04165070PHASE1, PHASE2RECRUITING

KEYMAKER-U01 Substudy 01A: Efficacy and Safety Study of Pembrolizumab (MK-3475) With or Without Chemotherapy When Used With Investigational Agents in Treatment-naïve Participants With Stage IV Non-small Cell Lung Cancer (NSCLC) (MK-3475-01A/KEYMAKER-U01A)

Sponsor · Merck Sharp & Dohme LLCCondition · Carcinoma, Non-Small-Cell LungIntervention · Pembrolizumab, CarboplatinUpdated May 2026
NCT06780111PHASE1, PHASE2RECRUITING

Substudy 06E: Umbrella Study of Combination Therapies in Esophageal Cancer (MK-3475-06E/KEYMAKER-U06)

Sponsor · Merck Sharp & Dohme LLCCondition · Esophageal Squamous Cell CarcinomaIntervention · Pembrolizumab, I-DXdUpdated Mar 2026
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