Showing studies matching your search13 results shown

Studies (13 shown)

NCT07517263PHASE3RECRUITING

An Open Label Extension (OLE) Study (Following Completion of CTQJ230A12301) to Evaluate Long-term Safety and Tolerability of Pelacarsen (TQJ230)

Sponsor · Novartis PharmaceuticalsCondition · Cardiovascular Disease and Lipoprotein(a)Intervention · Pelacarsen (TQJ230)Updated May 2026
NCT05646381PHASE2RECRUITING

A Multicenter Trial Assessing the Impact of Lipoprotein(a) Lowering With Pelacarsen (TQJ230) on the Progression of Calcific Aortic Valve Stenosis

Sponsor · Novartis PharmaceuticalsCondition · Aortic StenosisIntervention · Pelacarsen (TQJ230) 80mg, Matching placeboUpdated Apr 2026
NCT05305664PHASE3COMPLETED

A Multicenter Trial Assessing the Impact of Lipoprotein(a) Lowering With Pelacarsen (TQJ230) on the Rate of Weekly Lipoprotein Apheresis Sessions in Patients With Hyperlipoproteinemia(a) and Established Cardiovascular Disease in Germany

Sponsor · Novartis PharmaceuticalsCondition · Hyperlipoproteinemia(a)Intervention · Pelacarsen (TQJ230) 80 mg s.c., Corresponding PlaceboUpdated Feb 2025
NCT06875973PHASE3RECRUITING

Pelacarsen Roll-over Extension Program

Sponsor · Novartis PharmaceuticalsCondition · Atherosclerotic Cardiovascular DiseaseIntervention · Pelacarsen (TQJ230)Updated May 2026
NCT06813911PHASE3RECRUITING

Lp(a) Lowering Study of Pelacarsen (TQJ230) With Background Inclisiran in Participants With Elevated Lp(a) and Established ASCVD

Sponsor · Novartis PharmaceuticalsCondition · Atherosclerotic Cardiovascular Disease (ASCVD)Intervention · Pelacarsen, PlaceboUpdated May 2026
NCT04023552PHASE3ACTIVE_NOT_RECRUITING

Assessing the Impact of Lipoprotein (a) Lowering With Pelacarsen (TQJ230) on Major Cardiovascular Events in Patients With CVD

Sponsor · Novartis PharmaceuticalsCondition · Cardiovascular Disease and Lipoprotein(a)Intervention · TQJ230, PlaceboUpdated May 2026
NCT06267560PHASE3COMPLETED

Lp(a) Lowering Study of Pelacarsen (TQJ230) in US Black/African American and Hispanic Participants With Elevated Lp(a) and Established ASCVD

Sponsor · Novartis PharmaceuticalsCondition · Elevated Lp(a) and Established Atherosclerotic Cardiovascular DiseaseIntervention · TQJ230, PlaceboUpdated May 2026
NCT04993664NAWITHDRAWN

Influence of Pelacarsen on Patients After Myocardial Infarction With High Lp(a) Values (PEMILA)

Sponsor · University Medical Centre LjubljanaCondition · Acute Coronary Syndrome, LipoproteinemiaIntervention · Pelacarsen (TQJ230), PlaceboUpdated Jan 2022
NCT05900141PHASE3ACTIVE_NOT_RECRUITING

An Open Label Extension (OLE) Study to Evaluate Long-term Safety and Tolerability of Pelacarsen (TQJ230)

Sponsor · Novartis PharmaceuticalsCondition · Hyperlipoproteinemia (a)Intervention · PelacarsenUpdated Aug 2025
NCT05026996PHASE1COMPLETED

Study to Assess the Pharmacokinetics of Pelacarsen (TQJ230) in Participants With Mild Hepatic Impairment Compared to Matched Healthy Participants

Sponsor · Novartis PharmaceuticalsCondition · Hepatic ImpairmentIntervention · PelacarsenUpdated Oct 2024
NCT07000695AVAILABLE

Managed Access Programs for TQJ230, Pelacarsen

Sponsor · Novartis PharmaceuticalsCondition · Atherosclerotic Cardiovascular Disease, ASCVDIntervention · PelacarsenUpdated Jun 2025
NCT05337878PHASE1COMPLETED

A Study to Assess Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Pelacarsen (ISIS 681257) in Healthy Japanese Participants

Sponsor · Ionis Pharmaceuticals, Inc.Condition · Healthy ParticipantsIntervention · Placebo, PelacarsenUpdated Apr 2022
NCT03070782PHASE2COMPLETED

Phase 2 Study of ISIS 681257 (AKCEA-APO(a)-LRx) in Participants With Hyperlipoproteinemia(a) and Cardiovascular Disease

Sponsor · Akcea TherapeuticsCondition · Elevated Lipoprotein(a), Cardiovascular DiseaseIntervention · ISIS 681257, PlaceboUpdated Oct 2020
Showing top 13 results. See all 13 results on CT.gov →