Showing studies matching your search34 results shown

Studies (34 shown)

NCT07197008PHASE2NOT_YET_RECRUITING

Sacituzumab Tirumotecan (Sac-TMT) Plus Bevacizumab in 3rd Generation EGFR-TKI Treated Advanced EGFR-mutant Nonsquamous NSCLC With Brain Metastasis

Sponsor · Li-kun ChenCondition · Lung CancerIntervention · Sacituzumab tirumotecan (Sac-TMT) plus bevacizumabUpdated Sep 2025
NCT06469944PHASE1, PHASE2RECRUITING

Substudy 06C: A Study of Investigational Agents With Pembrolizumab (MK-3475) and Chemotherapy in Participants With First-Line Locally Advanced Unresectable/Metastatic Gastroesophageal Adenocarcinoma (MK-3475-06C/KEYMAKER-U06)

Sponsor · Merck Sharp & Dohme LLCCondition · Gastroesophageal Junction, Gastroesophageal AdenocarcinomaIntervention · Pembrolizumab, Sacituzumab Tirumotecan (sac-TMT)Updated May 2026
NCT07371208PHASE2RECRUITING

Multicenter, Phase II Clinical Study of Sacituzumab Tirumotecan (Sac-TMT) in Combination With KL-A167 for Neoadjuvant Treatment of Triple-Negative Breast Cancer

Sponsor · Shanghai Jiao Tong University School of MedicineCondition · Breast CancerIntervention · SKB264Updated Jan 2026
NCT06824467PHASE3RECRUITING

A Study to Evaluate the Efficacy and Safety of Sacituzumab Tirumotecan (MK-2870) Maintenance Treatment Versus Standard of Care in Participants With Platinum-sensitive Recurrent Ovarian Cancer (MK-2870-022/TroFuse-022/ENGOT-ov84/GOG-3103)

Sponsor · Merck Sharp & Dohme LLCCondition · Ovarian Cancer, Fallopian Tube CancerIntervention · Sacituzumab tirumotecan, BevacizumabUpdated May 2026
NCT07318558PHASE3RECRUITING

A Clinical Trial of Sac-TMT in People With Non-HRD Positive Advanced Ovarian Cancer (MK-2870-021)

Sponsor · Merck Sharp & Dohme LLCCondition · Ovarian Neoplasms, Ovarian CancerIntervention · Sacituzumab tirumotecan, BevacizumabUpdated May 2026
NCT07419295PHASE3RECRUITING

A Clinical Trial of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) to Treat Urothelial Cancer (MK-2870-031)

Sponsor · Merck Sharp & Dohme LLCCondition · Bladder CancerIntervention · Sacituzumab tirumotecan, VinflunineUpdated May 2026
NCT06841354PHASE3RECRUITING

A Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) as Monotherapy and in Combination With Pembrolizumab (MK-3475) in Participants With Triple-Negative Breast Cancer (MK-2870-011/TroFuse-011)

Sponsor · Merck Sharp & Dohme LLCCondition · Triple Negative Breast NeoplasmsIntervention · Sacituzumab tirumotecan, PembrolizumabUpdated May 2026
NCT06459180PHASE3ACTIVE_NOT_RECRUITING

A Study to Compare Sacituzumab Tirumotecan (MK-2870) Monotherapy Versus Treatment of Physician's Choice as Second-line Treatment for Participants With Recurrent or Metastatic Cervical Cancer (MK-2870-020/TroFuse-020/Gog-3101/ENGOT-cx20)

Sponsor · Merck Sharp & Dohme LLCCondition · Cervical CancerIntervention · Sacituzumab Tirumotecan, PemetrexedUpdated May 2026
NCT07286149PHASE1, PHASE2RECRUITING

A Clinical Study of MK-1084 With Other Treatments for Non-small Cell Lung Cancer (MK-3475-01F)

Sponsor · Merck Sharp & Dohme LLCCondition · Lung Neoplasm MalignantIntervention · MK-1084, Patritumab deruxtecanUpdated May 2026
NCT06952504PHASE3RECRUITING

A Study to Compare Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab (MK-3475) Versus Pembrolizumab Alone as Treatment in Participants With Mismatch Repair Proficient Endometrial Cancer (MK-2870-033/TroFuse-033/GOG-3119/ENGOT-en29)

Sponsor · Merck Sharp & Dohme LLCCondition · Endometrial CancerIntervention · Pembrolizumab, CarboplatinUpdated May 2026
NCT06966700PHASE3RECRUITING

A Clinical Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) in People With Breast Cancer (MK-2870-032)

Sponsor · Merck Sharp & Dohme LLCCondition · Breast Neoplasms, Triple Negative Breast NeoplasmsIntervention · Sacituzumab tirumotecan, PembrolizumabUpdated May 2026
NCT06422143PHASE3RECRUITING

Pembrolizumab With or Without Maintenance Sacituzumab Tirumotecan (Sac-TMT; MK-2870) in Metastatic Squamous Non-small Cell Lung Cancer (NSCLC) [MK-2870-023]

Sponsor · Merck Sharp & Dohme LLCCondition · Non-small Cell Lung Cancer, NSCLCIntervention · Pembrolizumab, sac-TMTUpdated May 2026
NCT07216703PHASE3RECRUITING

A Clinical Study of Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab (MK-3475) as First-line Maintenance Treatment of Cervical Cancer (MK-2870-036/TroFuse-036/GOG-3123/ENGOT-cx22)

Sponsor · Merck Sharp & Dohme LLCCondition · Cervical CancerIntervention · Pembrolizumab, Sacituzumab TirumotecanUpdated May 2026
NCT06312137PHASE3RECRUITING

A Study to Assess Efficacy and Safety of Pembrolizumab With or Without Sacituzumab Tirumotecan (MK- 2870) in Adult Participants With Resectable Non Small Cell Lung Cancer (NSCLC) Not Achieving Pathological Complete Response (pCR) (MK-2870-019)

Sponsor · Merck Sharp & Dohme LLCCondition · Non Small Cell Lung CancerIntervention · Sacituzumab tirumotecan, PembrolizumabUpdated May 2026
NCT06445972PHASE1, PHASE2RECRUITING

Substudy 06D: Combination Therapies in Second Line (2L) Gastroesophageal Adenocarcinoma (MK-3475-06D/Keymaker-U06)

Sponsor · Merck Sharp & Dohme LLCCondition · Gastroesophageal Junction, Gastroesophageal AdenocarcinomaIntervention · Ramucirumab, PaclitaxelUpdated May 2026
NCT07324629PHASE2NOT_YET_RECRUITING

Sacituzumab Tirumotecan in Participants With Locally Advanced or Metastatic Thymic Carcinoma

Sponsor · Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd.Condition · Thymic CarcinomaIntervention · Sacituzumab tirumotecanUpdated May 2026
NCT06637423PHASE1, PHASE2RECRUITING

A Clinical Study of Sacituzumab Tirumotecan (MK-2870) in Patients With Bladder Cancer (MK-2870-027)

Sponsor · Merck Sharp & Dohme LLCCondition · Non-Muscle Invasive Bladder CancerIntervention · Sacituzumab tirumotecan, Rescue medicationUpdated May 2026
NCT07521670PHASE2NOT_YET_RECRUITING

Sacituzumab Tirumotecan in Recurrent/Metastatic Adenoid Cystic Carcinoma and Papillary Thyroid Carcinoma (STRAP)

Sponsor · National Cancer Centre, SingaporeCondition · Recurrent Adenoid Cystic Carcinoma, Adenoid Cystic Carcinoma MetastaticIntervention · Sacituzumab TirumotecanUpdated Apr 2026
NCT07501169PHASE2NOT_YET_RECRUITING

Sacituzumab Tirumotecan in Combination With Anlotinib in Previously Treated Patients With Extensive-Stage Small Cell Lung Cancer (ES-SCLC)

Sponsor · Sichuan UniversityCondition · Extensive-stage Small Cell Lung Cancer (ES-SCLC)Intervention · Sacituzumab Tirumotecan and AnlotinibUpdated Apr 2026
NCT07256236PHASE2RECRUITING

SKB264 Plus QL1706 in Recurrent or Metastatic Cervical Cancer

Sponsor · Fujian Cancer HospitalCondition · Cervical CancerIntervention · Sacituzumab tirumotecan, QL1706Updated Mar 2026
NCT07458113PHASE2NOT_YET_RECRUITING

Sac-TMT for Active TNBC Brain Metastases

Sponsor · Yale UniversityCondition · Metastatic Triple Negative Breast CancersIntervention · Sacituzumab tirumotecanUpdated Mar 2026
NCT07343479PHASE2NOT_YET_RECRUITING

Sacituzumab Tirumotecan Plus Third-Generation TKI With/Without Radiotherapy for EGFR-Mutant NSCLC Brain Metastases

Sponsor · Zhejiang Cancer HospitalCondition · NSCLC (Advanced Non-small Cell Lung Cancer), EGFR Gene MutationsIntervention · sac-TMT plus EGFR-TKIUpdated Jan 2026
NCT07244874PHASE2NOT_YET_RECRUITING

Sac-TMT Combined With Toripalimab for First-line Treatment of PD-L1 Positive a/mTNBC

Sponsor · Tianjin Medical University Cancer Institute and HospitalCondition · TNBC - Triple-Negative Breast Cancer, PD-L1 PositiveIntervention · Sacituzumab tirumotecan, ToripalimabUpdated Nov 2025
NCT07244926PHASE2NOT_YET_RECRUITING

Sac-TMT Plus Bevacizumab as Second-Line Treatment for Advanced Non-Squamous Non-Small Cell Lung Cancer

Sponsor · Tianjin Medical University Cancer Institute and HospitalCondition · Lung CancerIntervention · Sacituzumab tirumotecan plus bevacizumabUpdated Nov 2025
NCT07054242PHASE2NOT_YET_RECRUITING

A Prospective, Single-center, Phase II Study of Sacituzumab Tirumotecan in Combination With Pembrolizumab for Neoadjuvant Treatment of Triple-Negative Breast Cancer (TNBC)

Sponsor · Yantai Yuhuangding HospitalCondition · Neoadjuvant Therapy, Stage II to III (T1cN1-2 or T2-4N0-2) TNBC Breast CancerIntervention · Sacituzumab Tirumotecan (SKB264) plus PembrolizumabUpdated Oct 2025
NCT07193160PHASE2NOT_YET_RECRUITING

Sacituzumab Tirumotecan in Combination With Furmonertinib as Second-line Treatment for EGFR-mutant Advanced or Metastatic NSCLC After Failure of First-line Third-generation EGFR-TKI Therapy

Sponsor · Fudan UniversityCondition · NSCLC (Non-small Cell Lung Cancer)Intervention · Sacituzumab Tirumotecan, FurmonertinibUpdated Sep 2025
NCT07179783PHASE2RECRUITING

Sacituzumab Tirumotecan in Combination With Tagitanlimab in the Treatment of Aggressive Variant Prostate Cancer (AVPC) and Neuroendocrine Prostate Cancer (NEPC)

Sponsor · Tianjin Medical University Second HospitalCondition · Prostate Cancer (Adenocarcinoma), Prostate Cancer Metastatic Castration-ResistantIntervention · Sacituzumab Tirumotecan, TagitanlimabUpdated Sep 2025
NCT07153965PHASE2NOT_YET_RECRUITING

Sacituzumab Tirumotecan Plus Tagitanlimab in Previously Treated Locally Advanced or Metastatic Triple Negative Breast Cancer

Sponsor · Tianjin Medical University Cancer Institute and HospitalCondition · Triple Negative Breast Cancer (TNBC), PD-L1 PositiveIntervention · Sacituzumab Tirumotecan plus TagitanlimabUpdated Sep 2025
NCT07139470PHASE1, PHASE2NOT_YET_RECRUITING

Sacituzumab Tirumotecan Plus Anlotinib for Metastatic Triple Negative Breast Cancer

Sponsor · Tianjin Medical University Cancer Institute and HospitalCondition · Triple Negative Breast CancerIntervention · Sacituzumab Tirumotecan + anlotinibUpdated Aug 2025
NCT07109284PHASE2NOT_YET_RECRUITING

SKB264 Combined With KL-A167 Neoadjuvant Therapy for Early-stage, High-risk ER+/HER2- Breast Cancer

Sponsor · West China HospitalCondition · ER+HER2- Breast CancerIntervention · Sacituzumab tirumotecan, TagitanlimabUpdated Aug 2025
NCT05319730PHASE1, PHASE2RECRUITING

A Study to Evaluate Investigational Agents With or Without Pembrolizumab (MK-3475) in Participants With Advanced Esophageal Cancer Previously Exposed to Programmed Cell Death 1 Protein (PD-1)/ Programmed Cell Death Ligand 1 (PD-L1) Treatment (MK-3475-06B)

Sponsor · Merck Sharp & Dohme LLCCondition · Esophageal Squamous Cell CarcinomaIntervention · Paclitaxel, IrinotecanUpdated May 2026
NCT04152499PHASE1, PHASE2ACTIVE_NOT_RECRUITING

Phase I-II, FIH, TROP2 ADC, Advanced Unresectable/Metastatic Solid Tumors, Refractory to Standard Therapies (KL264-01)

Sponsor · Klus Pharma Inc.Condition · Epithelial Ovarian Cancer, Gastric AdenocarcinomaIntervention · SKB264Updated May 2026
NCT07258108PHASE2RECRUITING

Sac-TMT Plus KL-A167 in PD-L1+, HR+/HER2- Metastatic Breast Cancer After CDK4/6 Inhibitors

Sponsor · Sun Yat-sen UniversityCondition · Breast CancerIntervention · Lucanisatuzumab plus tagolimumabUpdated May 2026
NCT05816252PHASE2ACTIVE_NOT_RECRUITING

A Study of SKB264 (MK-2870; Sac-TMT) for the Treatment of Participants With Advanced or Metastatic Non-small Cell Lung Cancer (SKB264-II-04) (MK-2870-003)

Sponsor · Klus Pharma Inc.Condition · Non-small Cell Lung CancerIntervention · SKB264, PembrolizumabUpdated Jan 2026
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