Showing studies matching your search15 results shown

Studies (15 shown)

NCT06129864PHASE3RECRUITING

A Global Study of Volrustomig (MEDI5752) for Participants With Unresected Locally Advanced Head and Neck Squamous Cell Carcinoma Following Definitive Concurrent Chemoradiotherapy

Sponsor · AstraZenecaCondition · Locally Advanced Head and Neck Squamous Cell CarcinomaIntervention · volrustomigUpdated May 2026
NCT05984277PHASE3ACTIVE_NOT_RECRUITING

A Global Study of Volrustomig (MEDI5752) Plus Chemotherapy Versus Pembrolizumab Plus Chemotherapy for Participants With Metastatic Non-small Cell Lung Cancer.

Sponsor · AstraZenecaCondition · Metastatic Non-small Cell Lung CancerIntervention · Volrustomig, PembrolizumabUpdated Mar 2026
NCT04541108EARLY_PHASE1ACTIVE_NOT_RECRUITING

Phase 0 Master Protocol for CIVO Intratumoral Microdosing of Anti-Cancer Therapies

Sponsor · Presage BiosciencesCondition · Solid TumorIntervention · Rilvegostomig, VolrustomigUpdated May 2026
NCT06943833PHASE2ACTIVE_NOT_RECRUITING

A Study of Volrustomig in Women With High Risk Locally Advanced Cervical Cancer (IVOLGA)

Sponsor · AstraZenecaCondition · Locally Advanced Cervical CancerIntervention · VolrustomigUpdated May 2026
NCT06448754PHASE2RECRUITING

Volrustomig Priming Regimens Exploratory Phase II Platform Study

Sponsor · AstraZenecaCondition · Non-small Cell Lung CancerIntervention · Volrustomig, CarboplatinUpdated May 2026
NCT06792695PHASE2RECRUITING

A Study of Novel Study Interventions and Combinations in Participants With Colorectal Cancer

Sponsor · AstraZenecaCondition · Metastatic Colorectal CancerIntervention · Volrustomig, FOLFIRI (Fluorouracil (5-FU), leucovorin, irinotecan)Updated May 2026
NCT06097728PHASE3RECRUITING

MEDI5752 in Combination With Carboplatin Plus Pemetrexed in Unresectable Pleural Mesothelioma

Sponsor · AstraZenecaCondition · Unresectable Pleural MesotheliomaIntervention · Volrustomig, PemetrexedUpdated Apr 2026
NCT05775159PHASE2RECRUITING

Study of Novel Immunomodulators as Monotherapy and in Combination With Anticancer Agents in Participants With Advanced Hepatobiliary Cancer

Sponsor · AstraZenecaCondition · Hepatocellular Carcinoma, Biliary Tract CancerIntervention · Volrustomig, BevacizumabUpdated Apr 2026
NCT05489211PHASE2RECRUITING

Study of Dato-DXd as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Tumours (TROPION-PanTumor03)

Sponsor · AstraZenecaCondition · Endometrial Cancer, Gastric CancerIntervention · Datopotamab deruxtecan (Dato-DXd), CapecitabineUpdated Mar 2026
NCT07000149PHASE3ACTIVE_NOT_RECRUITING

A Study to Investigate the Efficacy and Safety of Volrustomig ± Casdatifan vs Nivolumab + Ipilimumab as 1L Treatment for Advanced ccRCC

Sponsor · AstraZenecaCondition · Advanced Clear Cell Renal Cell CarcinomaIntervention · Volrustomig, CasdatifanUpdated Mar 2026
NCT05061550PHASE2RECRUITING

Neoadjuvant and Adjuvant Treatment in Resectable Non-small Cell Lung Cancer

Sponsor · AstraZenecaCondition · Non-small Cell Lung CancerIntervention · Durvalumab, OleclumabUpdated May 2026
NCT04379596PHASE2RECRUITING

Ph1b/2 Study of the Safety and Efficacy of T-DXd Combinations in Advanced HER2-expressing Gastric Cancer (DESTINY-Gastric03)

Sponsor · AstraZenecaCondition · Gastric CancerIntervention · Fluorouracil (5-FU), CapecitabineUpdated May 2026
NCT04686305PHASE1RECRUITING

Phase Ib Study of the Safety of T-DXd and Immunotherapy Agents With and Without Chemotherapy in Advanced or Metastatic HER2+, Non-squamous NSCLC

Sponsor · AstraZenecaCondition · Locally Advanced or Metastatic Non-Small Cell Lung CancerIntervention · T-DXd, DurvalumabUpdated Apr 2026
NCT04612751PHASE1ACTIVE_NOT_RECRUITING

Phase 1b Study of Dato-DXd in Combination With Immunotherapy With or Without Carboplatin in Advanced or Metastatic Non-Small Cell Lung Cancer

Sponsor · AstraZenecaCondition · Advanced or Metastatic NSCLCIntervention · Datopotamab deruxtecan, DurvalumabUpdated Apr 2026
NCT06366451EARLY_PHASE1RECRUITING

PBI-MST-01 (NCT04541108) Substudy AZN-05: Intratumoral Microdosing of Rilvegostomig, Volrustomig, Sabestomig, and AZD9592 in HNSCC

Sponsor · Presage BiosciencesCondition · Head and Neck Squamous Cell CarcinomaIntervention · Rilvegostomig, VolrustomigUpdated Jan 2025
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