Showing studies matching your search29 results shown

Studies (29 shown)

NCT06863311PHASE2RECRUITING

Trial of Zanzalintinib (XL092) in Combination With Immunotherapy in Patients Who Progress on Adjuvant Therapy in Clear Cell RCC

Sponsor · Karie RuncieCondition · Advanced Renal Cell Carcinoma, Metastatic Renal Cell CarcinomaIntervention · XL092, NivolumabUpdated May 2026
NCT06082167PHASE2, PHASE3ACTIVE_NOT_RECRUITING

Study of Zanzalintinib (XL092) + Pembrolizumab vs Pembrolizumab in Subjects With PD-L1 Positive Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma

Sponsor · ExelixisCondition · Head and Neck Squamous Cell CarcinomaIntervention · Zanzalintinib, Zanzalintinib-matched PlaceboUpdated Aug 2025
NCT06191796PHASE1TERMINATED

Study of Zanzalintinib (XL092) + AB521 and Zanzalintinib + AB521 + Nivolumab in Participants With Advanced Clear Cell Renal Cell Carcinoma (ccRCC) or Other Advanced Solid Tumors (STELLAR-009)

Sponsor · ExelixisCondition · Advanced Clear Cell Renal Cell Carcinoma or Other Advanced Solid TumorsIntervention · zanzalintinib, AB521Updated Jun 2025
NCT07489495PHASE3RECRUITING

A Clinical Study of Belzutifan (MK-6482) and Zanzalintinib in People With Renal Cell Carcinoma (RCC) (LITESPARK-034/LS-034/MK-6482-034)

Sponsor · Merck Sharp & Dohme LLCCondition · Carcinoma, Renal CellIntervention · Belzutifan, ZanzalintinibUpdated May 2026
NCT07428616PHASE2RECRUITING

A Study of Zanzalintinib in Participants With Recurrent or Progressive Meningioma

Sponsor · ExelixisCondition · MeningiomaIntervention · ZanzalintinibUpdated May 2026
NCT05176483PHASE1RECRUITING

Study of Zanzalintinib in Combination With Immuno-Oncology Agents in Participants With Solid Tumors

Sponsor · ExelixisCondition · Renal Cell Carcinoma (RCC), Metastatic Castration-Resistant Prostate Cancer (mCRPC)Intervention · Zanzalintinib, NivolumabUpdated May 2026
NCT07049926PHASE1, PHASE2RECRUITING

Substudy 03C: A Study of Combination Therapies in Participants With Renal Cell Carcinoma With Recurrent Disease During or After Anti-PD-(L)1 Therapy (MK-3475-03C/KEYMAKER-U03)

Sponsor · Merck Sharp & Dohme LLCCondition · Renal Cell CarcinomaIntervention · Belzutifan, ZanzalintinibUpdated May 2026
NCT06794229PHASE2RECRUITING

Neoadjuvant Zanzalintinib Plus Nivolumab in Patients With Locally Advanced and/or Inoperable Clear Cell Renal Cell Carcinoma With or Without Non-measurable Metastasis

Sponsor · Qian QinCondition · Locally Advanced Renal Cell CarcinomaIntervention · Zanzalintinib, NivolumabUpdated May 2026
NCT07227402PHASE3RECRUITING

A Clinical Study of Belzutifan and Zanzalintinib in People With Recurrent Kidney Cancer Following Adjuvant Therapy (MK-6482-033)

Sponsor · Merck Sharp & Dohme LLCCondition · Renal Cell CarcinomaIntervention · Belzutifan, ZanzalintinibUpdated May 2026
NCT07578025PHASE2NOT_YET_RECRUITING

Zanzalintinib and MO-03 for the Treatment of Metastatic Renal Cell Cancer After Progression on Immunotherapy

Sponsor · City of Hope Medical CenterCondition · Metastatic Clear Cell Renal Cell Carcinoma, Stage IV Renal Cell Cancer AJCC v8Intervention · Biospecimen Collection, Bone ScanUpdated May 2026
NCT07484139PHASE2NOT_YET_RECRUITING

H&N NEO-COMBAT XL: Neoadjuvant XL-092 (Zanzalintinib) and Pembrolizumab (Keytruda) in Surgically Resectable, HPV Negative Oral Cavity Squamous Cell Carcinoma (OCSCC)

Sponsor · UNC Lineberger Comprehensive Cancer CenterCondition · Oral Cavity Squamous Cell Carcinoma, Head and Neck CancerIntervention · XL092, PembrolizumabUpdated May 2026
NCT07043608PHASE2NOT_YET_RECRUITING

Zanzalintinib for Metastatic Clear Cell Renal Cell Carcinoma With Bone Metastases

Sponsor · Kelly Fitzgerald, MDCondition · Clear Cell Renal Cell Cancer (ccRCC), Clear Cell Renal CarcinomaIntervention · Zanzalintinib, Investigator Choice of Bone Strengthening Agents (BSA)Updated May 2026
NCT06943755PHASE2, PHASE3RECRUITING

Zanzalintinib Versus Everolimus in Participants With Locally Advanced or Metastatic Neuroendocrine Tumors

Sponsor · ExelixisCondition · Pancreatic Neuroendocrine Tumor (pNET), Extra-Pancreatic Neuroendocrine Tumor (epNET)Intervention · Zanzalintinib, EverolimusUpdated Apr 2026
NCT07470489PHASE2NOT_YET_RECRUITING

Zanzalintinib Plus Cemiplimab for the Treatment of BRAF Wild-Type Anaplastic Thyroid Cancer

Sponsor · M.D. Anderson Cancer CenterCondition · Anaplastic Thyroid CancerIntervention · Cemiplimab, ZanzalintinibUpdated Apr 2026
NCT07527169PHASE2NOT_YET_RECRUITING

A Phase 2 Study Of Zanzalintinib For Patients With Recurrent Or Metastatic Olfactory Neuroblastoma

Sponsor · M.D. Anderson Cancer CenterCondition · Metastatic Olfactory NeuroblastomaIntervention · ZanzalintinibUpdated Apr 2026
NCT07511504PHASE2NOT_YET_RECRUITING

Y-90 Radioembolization, Durvalumab, Tremelimumab, and Zanzalintinib for the Treatment of Unresectable and Locally-Advanced Hepatocellular Carcinoma

Sponsor · OHSU Knight Cancer InstituteCondition · Locally Advanced Hepatocellular Carcinoma, Stage III Hepatocellular Carcinoma AJCC v8Intervention · Angiogram, Biopsy ProcedureUpdated Apr 2026
NCT06959641PHASE2RECRUITING

XL092 for the Treatment of Locally Advanced or Metastatic Radioiodine Refractory Differentiated Thyroid Cancer

Sponsor · Northwestern UniversityCondition · Locally Advanced Differentiated Thyroid Gland Carcinoma, Locally Advanced Poorly Differentiated Thyroid Gland CarcinomaIntervention · Biospecimen Collection, Computed TomographyUpdated May 2026
NCT07193550PHASE2RECRUITING

A Phase 2 Trial of Zanzalintinib in Advanced/Metastatic Bone Sarcomas (ZAMBONE)

Sponsor · M.D. Anderson Cancer CenterCondition · Bone SarcomasIntervention · ZanzalintinibUpdated Feb 2026
NCT06571734PHASE2RECRUITING

XL092 (Zanzalintinib) for the Treatment of Patients With Metastatic or Unresectable Leiomyosarcoma

Sponsor · Northwestern UniversityCondition · Metastatic Leiomyosarcoma, Unresectable LeiomyosarcomaIntervention · Biospecimen Collection, Computed TomographyUpdated Jan 2026
NCT06968988PHASE1RECRUITING

Zanzalintinib in Combination With Ipilimumab and Nivolumab in Patients With Metastatic Soft Tissue Sarcoma

Sponsor · Washington University School of MedicineCondition · Metastatic Soft-tissue SarcomaIntervention · Zanzalintinib, IpilimumabUpdated Jan 2026
NCT06795009PHASE1RECRUITING

Zanzalintinib in Combination With Paclitaxel in Recurrent High Grade Uterine Cancer

Sponsor · Washington University School of MedicineCondition · Uterine Cancer, Endometrial CancerIntervention · Zanzalintinib, PaclitaxelUpdated Dec 2025
NCT06912087PHASE1RECRUITING

Dose Finding Study of Zanzalintinib With Pembrolizumab and Cetuximab in Head and Neck SCC

Sponsor · University of ChicagoCondition · Head and Neck Neoplasms, Carcinoma, Squamous CellIntervention · Zanzalintinib, CetuximabUpdated Dec 2025
NCT06698250PHASE2RECRUITING

Zanzalintinib (XL-092) Plus Durvalumab and Tremelimumab in Unresectable Hepatocellular Carcinoma (ZENOBIA)

Sponsor · Anwaar SaeedCondition · Hepatocellular CarcinomaIntervention · Zanzalintinib, DurvalumabUpdated Nov 2025
NCT06957431PHASE1RECRUITING

Zanzalintinib Combined With Eribulin in Advanced Liposarcoma and Leiomyosarcoma

Sponsor · Washington University School of MedicineCondition · Advanced Leiomyosarcoma, Adipocytic SarcomaIntervention · Zanzalintinib, EribulinUpdated Oct 2025
NCT07218666PHASE2NOT_YET_RECRUITING

Zanzalintinib in Men With Aggressive Variant Prostate Cancer

Sponsor · Deepak KilariCondition · Aggressive Variant Prostate CarcinomaIntervention · ZanzalintinibUpdated Oct 2025
NCT07042919PHASE1, PHASE2NOT_YET_RECRUITING

Zanzalintinib in Second Line and Beyond for the Treatment of Advanced Liver Cancer

Sponsor · Northwestern UniversityCondition · Advanced Hepatocellular Carcinoma, CirrhosisIntervention · Biospecimen Collection, Computed TomographyUpdated Jun 2025
NCT06962332PHASE1RECRUITING

Pharmacokinetics (PK) and Safety of Zanzalintinib in Participants With Moderate Hepatic Impairment (HI)

Sponsor · ExelixisCondition · Hepatic Impairment, Moderate Hepatic ImpairmentIntervention · ZanzalintinibUpdated Jun 2025
NCT03337698PHASE1, PHASE2TERMINATED

A Study Of Multiple Immunotherapy-Based Treatment Combinations In Participants With Metastatic Non-Small Cell Lung Cancer (Morpheus- Non-Small Cell Lung Cancer)

Sponsor · Hoffmann-La RocheCondition · Carcinoma, Non-Small-Cell LungIntervention · Atezolizumab, CobimetinibUpdated May 2026
NCT06568562PHASE2RECRUITING

XL092 in Patients With Metastatic Castration-Resistant Prostate Cancer

Sponsor · University of UtahCondition · Metastatic Castration-resistant Prostate CancerIntervention · XL092Updated Dec 2025
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