Showing studies matching your search10 results shown

Studies (10 shown)

NCT05139017PHASE2, PHASE3RECRUITING

A Study of Zilovertamab Vedotin (MK-2140) in Combination With Standard of Care in Participants With Relapsed or Refractory Diffuse Large B-Cell Lymphoma (rrDLBCL) (MK-2140-003)

Sponsor · Merck Sharp & Dohme LLCCondition · DLBCL, Diffuse Large B-Cell LymphomaIntervention · Zilovertamab vedotin, RituximabUpdated May 2026
NCT06890884PHASE2RECRUITING

A Clinical Study of Zilovertamab Vedotin (MK-2140) Plus Rituximab Plus Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Polatuzumab Vedotin Plus R-CHP in People With Diffuse Large B-cell Lymphoma (DLBCL) (MK-2140-011/waveLINE-011)

Sponsor · Merck Sharp & Dohme LLCCondition · Lymphoma, Large B-Cell, DiffuseIntervention · Zilovertamab vedotin, RituximabUpdated May 2026
NCT06717347PHASE3RECRUITING

A Study to Evaluate Zilovertamab Vedotin (MK-2140) Combination With Rituximab Plus Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Rituximab Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (R-CHOP) in Participants With Previously Untreated DLBCL (MK-2140-010)

Sponsor · Merck Sharp & Dohme LLCCondition · Diffuse Large B-Cell LymphomaIntervention · Zilovertamab vedotin, RituximabUpdated May 2026
NCT05458297PHASE2ACTIVE_NOT_RECRUITING

A Study of Zilovertamab Vedotin (MK-2140) as Monotherapy and in Combination in Participants With Aggressive and Indolent B-cell Malignancies (MK-2140-006)

Sponsor · Merck Sharp & Dohme LLCCondition · Chronic Lymphocytic Leukemia, Mantle Cell LymphomaIntervention · Zilovertamab vedotin, NemtabrutinibUpdated May 2026
NCT06395103PHASE1, PHASE2RECRUITING

Substudy 01A: Zilovertamab Vedotin in Pediatric and Young Adult Participants With Hematologic Malignancies or Solid Tumors (MK-9999-01A/LIGHTBEAM-U01)

Sponsor · Merck Sharp & Dohme LLCCondition · B-cell Acute Lymphoblastic Leukemia, Diffuse Large B-cell LymphomaIntervention · Zilovertamab vedotinUpdated May 2026
NCT05144841PHASE2COMPLETED

A Study to Evaluate Zilovertamab Vedotin (MK-2140) for Relapsed or Refractory Diffuse Large B-Cell Lymphoma (DLBCL) (MK-2140-004)

Sponsor · Merck Sharp & Dohme LLCCondition · Relapsed or Refractory Diffuse Large B-Cell LymphomaIntervention · Zilovertamab vedotinUpdated May 2026
NCT05406401PHASE2ACTIVE_NOT_RECRUITING

A Study of Zilovertamab Vedotin (MK-2140) in Combination With Cyclophosphamide, Doxorubicin, and Prednisone Plus Rituximab or Rituximab Biosimilar (Truxima) (R-CHP) in Participants With Diffuse Large B-Cell Lymphoma (DLBCL) (MK-2140-007)

Sponsor · Merck Sharp & Dohme LLCCondition · Lymphoma, Large B-Cell, Diffuse (DLBCL)Intervention · Zilovertamab Vedotin, CyclophosphamideUpdated Oct 2024
NCT04504916PHASE2TERMINATED

A Study of Zilovertamab Vedotin (MK-2140/VLS-101) in Participants With Solid Tumors (MK-2140-002)

Sponsor · VelosBio Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)Condition · Triple-negative Breast Cancer, Non-squamous Non-small-cell Lung CancerIntervention · Zilovertamab vedotinUpdated Nov 2025
NCT03833180PHASE1COMPLETED

A Study of Zilovertamab Vedotin (MK-2140) (VLS-101) in Participants With Hematologic Malignancies (MK-2140-001)

Sponsor · VelosBio Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)Condition · Chronic Lymphocytic Leukemia, Mantle Cell LymphomaIntervention · Zilovertamab vedotinUpdated Jan 2024
NCT05562830PHASE1, PHASE2RECRUITING

A Substudy of Investigational Agents in Programmed Cell Death-1/Ligand 1 (PD-1/L1) Refractory Locally Advanced or Metastatic Urothelial Carcinoma (mUC) (MK-3475-04A)

Sponsor · Merck Sharp & Dohme LLCCondition · Urothelial CarcinomaIntervention · Zilovertamab vedotin, PembrolizumabUpdated May 2026
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