Can (Optical Coherence Tomography) Pictures of the Retina Detect Alzheimer's Disease at Its Earliest Stages?

No open prediction endpoints

Endpoints are classified and published by ProgramSignal analysts.

Key Facts

Primary Endpoints (CT.gov)

Eligibility Criteria

Inclusion Criteria: * By clinician (or prior research) assessment, known to either be cognitively normal, or have mild cognitive impairment * Known Alzheimer's biomarker status. As of 2023-JUL, this must either be an amyloid PET scan, or cerebrospinal fluid measurement of amyloid and tau levels. * NOTE: Although this is a study of the eyes, age-typical ocular/vision complaints are permissible, so long as the the retina is thought to be healthy. This list of acceptable conditions includes most people who: * wear glasses * wear contacts * use over-the-counter eye drops * have mild cataracts (no surgery scheduled) * had cataracts removed * had eye muscle surgery (e.g., to correct eye misalignment) * had eyelid surgery (blepharoplasty) * are monitored by an ophthalmologist in case a problem with the retina develops (this is sometimes suggested for people with diabetes), but one or both retinas is/are thought to be completely healthy Exclusion Criteria: * Pregnant women …

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