A Drug-Drug Interaction Study of LY3537982 on Midazolam, Digoxin, and Rosuvastatin in Healthy Participants
A PHASE 1 STUDY TO EVALUATE THE EFFECTS OF MULTIPLE DOSES OF LY3537982 ON THE SINGLE-DOSE PHARMACOKINETICS OF MIDAZOLAM, DIGOXIN, AND ROSUVASTATIN IN HEALTHY ADULT SUBJECTS
Sponsor: Eli Lilly and Company + Loxo Oncology, Inc.
No open prediction endpoints
Endpoints are classified and published by ProgramSignal analysts.
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Primary Endpoints (CT.gov)
Part 1: Pharmacokinetics (PK): Maximum Observed Concentration (Cmax) of LY3537982
Time frame: Predose on day 11 up to day 17
Part 1: PK: Area Under the Concentration-Time Curve (AUC) from Time 0 to Infinity (AUC[0-inf]) of LY3537982
Time frame: Predose on day 11 up to day 17
Part 1: PK: AUC from Time 0 to time of the last measurable concentration (AUClast) of LY3537982
Time frame: Predose on day 11 up to day 17
Part 1: PK: Cmax of Digoxin
Time frame: Predose on day 1 up to day 21
Eligibility Criteria
Inclusion Criteria: * Healthy status as defined by the absence of evidence of any clinically significant active or chronic disease * Body mass index (BMI): 18.0 to 32.0 kilograms per square meter (kg/m²), inclusive Exclusion Criteria: * Females who are lactating or of childbearing potential * Clinically significant history of any drug sensitivity, drug allergy, or food allergy
✦ Analyst Commentary
Expert commentary on why this trial matters and what to watch for.
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