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NCT06991491PHASE2NOT_YET_RECRUITING

Ivonescimab With GnP and SBRT in Patients With Metastatic Pancreatic Cancer (WGOG-PAN 004)

Ivonescimab With GnP and SBRT in Patients With Metastatic Pancreatic Cancer (WGOG-PAN 004): an Open-label, Single-arm, Phase II Trial of First-line Multimodal Therapy With Spatial Tumor Immune Microenvironment Analysis

Sponsor: West China Hospital

No open prediction endpoints

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Key Facts

Study type
INTERVENTIONAL
Conditions
Pancreatic Cancer
Interventions
GnP in combination with Ivonescimab and SBRT
Enrollment
29 participants
Primary completion
Jun 2026
Study completion
Sep 2026
First posted
May 2025
Last updated
May 2025

Primary Endpoints (CT.gov)

6-month-PFS rate

Time frame: Follow up with patients for up to 24 months

Eligibility Criteria

Inclusion Criteria: 1. Patients with pathologically confirmed metastatic pancreatic cancer; 2. Patients who have not received any prior systemic anti-tumor therapy, or who have undergone prior radical pancreatic cancer surgery and received regular postoperative adjuvant chemotherapy, and who have developed recurrence or metastasis more than 6 months after final adjuvant chemotherapy; 3. Aged 18 to 75 years old; 4. Eastern Cooperative Oncology Group performance status score (ECOG) ≤ 2; 5. According to imaging and surgical evaluation, the liver lesion is unresectable or rhe patient is unable to tolerate surgery, and the primary lesion has no serious complications (perforation, obstruction or hemorrhea that cannot be managed by medical therapy); 6. At least one measurable tumor lesion: length and diameter of spiral CT greater than or equal to 10 mm, lymph node short diameter greater than or equal to 15 mm; maximum diameter of conventional CT or physical examination greater than or equal

Read full criteria on CT.gov →

✦ Analyst Commentary

Expert commentary on why this trial matters and what to watch for.

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Source

Open on ClinicalTrials.gov