AK112 Plus FOLFIRI Versus Bevacizumab Plus FOLFIRI as Second-line Treatment of MSS/pMMR Metastatic Colorectal Cancer

No open prediction endpoints

Endpoints are classified and published by ProgramSignal analysts.

Key Facts

Primary Endpoints (CT.gov)

Secondary Endpoints

Eligibility Criteria

Inclusion Criteria: 1. Voluntarily sign written informed consent 2. Agree to provide tumor and blood samples for biomarker detection 3. Age ≥18 and ≤75 years at enrollment, regardless of gender 4. Eastern Cooperative Oncology Group (ECOG) performance status score of 0 or 1 5. Expected survival ≥3 months 6. Pathologically confirmed locally advanced unresectable or metastatic colorectal adenocarcinoma 7. Confirmed MSS/pMMR-type CRC by immunohistochemistry (IHC), PCR, or NGS 8. Intolerance to oxaliplatin-containing standard first-line therapy, disease progression, or recurrence within \< 6 months after oxaliplatin adjuvant therapy 9. Adequate organ function (last 14 days without intervention): 1. Absolute neutrophil count (ANC) ≥1.5×10⁹/L without granulocyte colony-stimulating factor1. 2. Platelets ≥100×10⁹/L without transfusion1. 3. Hemoglobin \>9 g/dL without transfusion or erythropoietin1. 4. Total bilirubin ≤1.5×ULN1. 5. AST/ALT ≤2.5×ULN1. 6. Serum creatinine ≤1.5×…

✦ Analyst Commentary

Expert commentary on why this trial matters and what to watch for.

Source