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NCT07416162NOT_YET_RECRUITING

A Study of Iptacopan in Korean Patients With Paroxysmal Nocturnal Hemoglobinuria or C3 Glomerulopathy

A Post-marketing Surveillance of Fabhalta® (Iptacopan) in Korean Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH) or C3 Glomerulopathy (C3G)

Sponsor: Novartis Pharmaceuticals

No open prediction endpoints

Endpoints are classified and published by ProgramSignal analysts.

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Key Facts

Study type
OBSERVATIONAL
Conditions
Paroxysmal Nocturnal Hemoglobinuria, C3 Glomerulopathy
Interventions
Enrollment
21 participants
Primary completion
Feb 2029
Study completion
Feb 2029
First posted
Feb 2026
Last updated
Apr 2026

Primary Endpoints (CT.gov)

Incidence Rate of Adverse Events (AE), Serious Adverse Events (SAE), and Adverse Drug Reactions (ADR)

Time frame: Up to 2 years

Secondary Endpoints

Hemoglobin Levels

Lactate Dehydrogenase (LDH) levels

White Blood Cell Count (WBC)

Eligibility Criteria

Inclusion criteria: 1. Patients aged 18 years or older who have been diagnosed with PNH or C3G. 2. Patients who have received vaccination in accordance with the approved Korean labeling prior to initiating treatment with iptacopan. 3. Patients who are being treated or will be treated with iptacopan in accordance with the approved Korean labeling. 4. Patients who have voluntarily provided consent for study participation (written informed consent). Exclusion criteria: 1. Patients who fall under the contraindications for iptacopan administration according to approved Korean labeling. 2. Patients for whom iptacopan administration is deemed inappropriate based on the investigator's judgment.

✦ Analyst Commentary

Expert commentary on why this trial matters and what to watch for.

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Source

Open on ClinicalTrials.gov