Showing studies matching your search100 results shown

Studies (100 shown)

NCT02531516PHASE3ACTIVE_NOT_RECRUITING

An Efficacy and Safety Study of JNJ-56021927 (Apalutamide) in High-risk Prostate Cancer Subjects Receiving Primary Radiation Therapy: ATLAS

Sponsor · Aragon Pharmaceuticals, Inc.Condition · Prostatic NeoplasmsIntervention · Apalutamide, BicalutamideUpdated May 2026
NCT01171898PHASE1, PHASE2COMPLETED

Safety, Pharmacokinetic and Proof-of-Concept Study of ARN-509 (Apalutamide) in Castration-Resistant Prostate Cancer (CRPC)

Sponsor · Aragon Pharmaceuticals, Inc.Condition · Prostate CancerIntervention · ARN-509 (Phase 1), ARN-509 (Phase 2)Updated May 2026
NCT04530552PHASE2ACTIVE_NOT_RECRUITING

Testing the Effects of Low Dose Apalutamide on Prostate-Specific Antigen (PSA) Levels in Men Scheduled for Removal of the Prostate Gland

Sponsor · National Cancer Institute (NCI)Condition · Localized Prostate Carcinoma, Prostate AdenocarcinomaIntervention · Apalutamide, Biospecimen CollectionUpdated May 2026
NCT07611110PHASE3RECRUITING

AZD2265 Compared With Standard of Care in PSMA-positive Metastatic Castration-resistant Prostate Cancer (VECTRA-01)

Sponsor · AstraZenecaCondition · Metastatic Castration-resistant Prostate CancerIntervention · AZD2265, CabazitaxelUpdated May 2026
NCT05849298PHASE2ACTIVE_NOT_RECRUITING

A Phase II Study of AAA617 Alone and AAA617 in Combination With ARPI in Patients With PSMA PET Scan Positive CRPC

Sponsor · Novartis PharmaceuticalsCondition · Prostatic NeoplasmIntervention · AAA617, AAA517Updated May 2026
NCT06274047PHASE3RECRUITING

PROSTATE-IQ: Parallel RandOmized STudy of Personalized Apalutamide Treatment and Evaluation to Improve Quality of Life in Post-Operative Radiation With Androgen Axis Suppression. A Phase III Multi-center Study for Men With Detectable PSA After Prostatectomy for Prostate Cancer.

Sponsor · M.D. Anderson Cancer CenterCondition · Androgen Axis Suppression, ProstatectomyIntervention · Apalutamide, Androgen Deprivation TherapyUpdated May 2026
NCT07592910PHASE2NOT_YET_RECRUITING

A Study of Mevrometostat With Enzalutamide in People With Prostate Cancer Who Have Previously Received Androgen Receptor Pathway Inhibitor Therapy

Sponsor · Prostate Cancer Clinical Trials ConsortiumCondition · Metastatic Castrate Resistant Prostate Cancer (mCRPC), Prostate Cancer (Adenocarcinoma)Intervention · Mevrometostat, EnzalutamideUpdated May 2026
NCT07223372RECRUITING

An Observational Study to Learn More About How Medicines That Block Male Hormones Are Used in People With Prostate Cancer in Australia

Sponsor · BayerCondition · Metastatic Hormonesensitive Prostate Cancer (mHSPC)Updated May 2026
NCT04947254PHASE2RECRUITING

Androgen Ablation Therapy With or Without Niraparib After Radiation Therapy for the Treatment of High-Risk Localized or Locally Advanced Prostate Cancer

Sponsor · M.D. Anderson Cancer CenterCondition · Prostate Carcinoma, Stage IIC Prostate Cancer AJCC v8Intervention · Abiraterone Acetate, Antiandrogen TherapyUpdated May 2026
NCT04423211PHASE3RECRUITING

Treating Prostate Cancer That Has Come Back After Surgery With Apalutamide and Targeted Radiation Based on PET Imaging

Sponsor · ECOG-ACRIN Cancer Research GroupCondition · Biochemically Recurrent Prostate Carcinoma, Metastatic Prostate CarcinomaIntervention · 3-Dimensional Conformal Radiation Therapy, ApalutamideUpdated May 2026
NCT04108208PHASE4ACTIVE_NOT_RECRUITING

A Study of Apalutamide in Chinese Participants With Non Metastatic Castration Resistant Prostate Cancer (NM-CRPC)

Sponsor · Janssen Research & Development, LLCCondition · Prostatic NeoplasmsIntervention · Apalutamide, PlaceboUpdated May 2026
NCT01946204PHASE3ACTIVE_NOT_RECRUITING

A Study of Apalutamide (ARN-509) in Men With Non-Metastatic Castration-Resistant Prostate Cancer

Sponsor · Aragon Pharmaceuticals, Inc.Condition · Prostatic NeoplasmsIntervention · Apalutamide, PlaceboUpdated May 2026
NCT02257736PHASE3ACTIVE_NOT_RECRUITING

An Efficacy and Safety Study of Apalutamide (JNJ-56021927) in Combination With Abiraterone Acetate and Prednisone Versus Abiraterone Acetate and Prednisone in Participants With Chemotherapy-naive Metastatic Castration-resistant Prostate Cancer (mCRPC)

Sponsor · Aragon Pharmaceuticals, Inc.Condition · Prostatic NeoplasmsIntervention · Apalutamide, Abiraterone acetateUpdated May 2026
NCT02489318PHASE3ACTIVE_NOT_RECRUITING

A Study of Apalutamide (JNJ-56021927, ARN-509) Plus Androgen Deprivation Therapy (ADT) Versus ADT in Participants With mHSPC

Sponsor · Aragon Pharmaceuticals, Inc.Condition · Prostate CancerIntervention · Apalutamide, PlaceboUpdated May 2026
NCT04325828PHASE2ACTIVE_NOT_RECRUITING

A Study of Apalutamide Combined With GnRH Agonist in Participants With Androgen Receptor Positive Salivary Gland Carcinoma

Sponsor · Janssen Pharmaceutical K.K.Condition · Salivary Gland NeoplasmsIntervention · Apalutamide, GnRH AgonistUpdated May 2026
NCT07451002RECRUITING

A Study to Assess Adherence to Apalutamide in Metastatic Hormone-Sensitive Prostate Cancer Participants in France

Sponsor · Janssen Cilag S.A.S.Condition · Prostatic Neoplasms, Metastatic Hormone-sensitive Prostate CancerUpdated May 2026
NCT04557059PHASE3ACTIVE_NOT_RECRUITING

A Study of Adding Apalutamide to Radiotherapy and LHRH Agonist in High-Risk Patients With Hormone-Sensitive Prostate Cancer

Sponsor · Janssen Pharmaceutica N.V., BelgiumCondition · Prostatic NeoplasmsIntervention · Radiotherapy, LHRHaUpdated May 2026
NCT03523442PHASE1ACTIVE_NOT_RECRUITING

A Study of Androgen Receptor (AR) Antagonist Apalutamide in Chinese Participants With Metastatic Castration-Resistant Prostate Cancer

Sponsor · Janssen Research & Development, LLCCondition · Prostatic NeoplasmsIntervention · ApalutamideUpdated May 2026
NCT04662580PHASE1ACTIVE_NOT_RECRUITING

ARX517/JNJ-95298177 as Monotherapy or Combination Therapy in Subjects With Metastatic Prostate Cancer

Sponsor · Janssen Research & Development, LLCCondition · Metastatic Prostate CancerIntervention · ARX517, ApalutamideUpdated May 2026
NCT05818683PHASE1RECRUITING

A Study of Pasritamig (JNJ-78278343) in Combination With Other Agents for Metastatic Prostate Cancer

Sponsor · Janssen Research & Development, LLCCondition · Metastatic Castration-resistant Prostate Neoplasms, Metastatic Hormone-sensitive Prostate CancerIntervention · Pasritamig, CetrelimabUpdated May 2026
NCT05901649ACTIVE_NOT_RECRUITING

A Study for the Participants With Metastatic Hormone Sensitive Prostate Cancer (mHSPC) Treated With Androgen Deprivation Therapy (ADT) Plus Apalutamide or Enzalutamide

Sponsor · Janssen-Cilag Ltd.Condition · Metastatic Hormone-sensitive Prostate CancerIntervention · Apalutamide, EnzalutamideUpdated May 2026
NCT03767244PHASE3ACTIVE_NOT_RECRUITING

A Study of Apalutamide in Participants With High-Risk, Localized or Locally Advanced Prostate Cancer Who Are Candidates for Radical Prostatectomy

Sponsor · Janssen Research & Development, LLCCondition · Prostatic NeoplasmsIntervention · Apalutamide, Androgen Deprivation Therapy (ADT)Updated May 2026
NCT06931340PHASE3RECRUITING

Testing the Addition of Docetaxel (Chemotherapy) to the Usual Treatment (Hormonal Therapy and Apalutamide) for Metastatic Prostate Cancer, ASPIRE Trial

Sponsor · Alliance for Clinical Trials in OncologyCondition · Castration-Sensitive Prostate Carcinoma, Metastatic Prostate AdenocarcinomaIntervention · Androgen Therapy, ApalutamideUpdated May 2026
NCT02123758PHASE1ACTIVE_NOT_RECRUITING

A Study of JNJ-56021927 (ARN-509) and Abiraterone Acetate in Participants With Metastatic Castration-Resistant Prostate Cancer

Sponsor · Aragon Pharmaceuticals, Inc.Condition · Prostatic Neoplasms, Metastatic Castration-Resistant Prostate CancerIntervention · Abiraterone Acetate, PrednisoneUpdated May 2026
NCT04134260PHASE3RECRUITING

Testing the Addition of the Drug Apalutamide to the Usual Hormone Therapy and Radiation Therapy After Surgery for Prostate Cancer, INNOVATE Trial

Sponsor · NRG OncologyCondition · Prostate Adenocarcinoma, Stage I Prostate Cancer AJCC v8Intervention · Apalutamide, Biospecimen CollectionUpdated May 2026
NCT06616155PHASE1, PHASE2RECRUITING

Ruxolitinib and Enzalutamide for the Treatment of Metastatic Castration-Resistant Prostate Cancer

Sponsor · University of Michigan Rogel Cancer CenterCondition · Castration-Resistant Prostate Carcinoma, Metastatic Prostate AdenocarcinomaIntervention · Biopsy, Biospecimen CollectionUpdated May 2026
NCT06095089PHASE1RECRUITING

A Study of JNJ-87189401 Combined With JNJ-78278343 for Advanced Prostate Cancer

Sponsor · Janssen Research & Development, LLCCondition · Prostatic NeoplasmsIntervention · JNJ-78278343, JNJ-87189401Updated May 2026
NCT04513717PHASE3ACTIVE_NOT_RECRUITING

Two Studies for Patients With High Risk Prostate Cancer Testing Less Intense Treatment for Patients With a Low Gene Risk Score and Testing a More Intense Treatment for Patients With a High Gene Risk Score, The PREDICT-RT Trial

Sponsor · NRG OncologyCondition · Prostate Adenocarcinoma, Stage III Prostate Cancer AJCC v8Intervention · Apalutamide, BicalutamideUpdated May 2026
NCT06894511PHASE2ACTIVE_NOT_RECRUITING

An Open-label Study of Lutetium (177Lu) Vipivotide Tetraxetan (AAA617) in Combination With ARPI Versus AAA617 in PSMA Positive First-line mCRPC

Sponsor · Novartis PharmaceuticalsCondition · Metastatic Castration Resistant Prostate Cancer (mCRPC)Intervention · AAA617, ARPI: AbirateroneUpdated May 2026
NCT07181122RECRUITING

Quality of Life, Functional and Cognitive Outcomes in Patients With Metastatic Hormone-Sensitive Prostate Cancer

Sponsor · Ankara Etlik City HospitalCondition · Metastatic Hormone-Sensitive Prostate Cancer (mHSPC)Intervention · Androgen Receptor Pathway Inhibitors (ARPIs)Updated Apr 2026
NCT03436654PHASE2ACTIVE_NOT_RECRUITING

Multi-arm Multi-modality Therapy for Very High Risk Localized and Low Volume Metastatic Prostatic Adenocarcinoma

Sponsor · Memorial Sloan Kettering Cancer CenterCondition · Prostate CancerIntervention · Apalutamide, Abiraterone AcetateUpdated Apr 2026
NCT07224009PHASE2NOT_YET_RECRUITING

Low Dose Naltrexone (LDN) for Management of Fatigue in Prostate Cancer Patients on Androgen Deprivation Therapy (ADT)

Sponsor · University of ArkansasCondition · Metastatic Prostate CancerIntervention · NaltrexoneUpdated Apr 2026
NCT04946370PHASE1, PHASE2RECRUITING

Phase I/II Trial of Pembrolizumab and Androgen-receptor Inhibitor With or Without 225Ac-J591 for Progressive Metastatic Castration Resistant Prostate Cancer

Sponsor · Weill Medical College of Cornell UniversityCondition · Prostate CancerIntervention · 225Ac-J591, PembrolizumabUpdated Apr 2026
NCT06378866PHASE2RECRUITING

Stereotactic Body Radiation Therapy Plus Immediate or Delayed Androgen Receptor Pathway Inhibitor and Androgen Deprivation Therapy or Salvage Radiation Therapy for the Treatment of Prostate Cancer, DIVINE Trial

Sponsor · Mayo ClinicCondition · Recurrent Castration-Sensitive Prostate Carcinoma, Recurrent Prostate CancerIntervention · Abiraterone, ApalutamideUpdated Apr 2026
NCT05766371PHASE2RECRUITING

Pembrolizumab Plus 177Lu-PSMA-617 in Patients With Castration Resistant Prostate Cancer

Sponsor · University of California, San FranciscoCondition · Castrate Resistant Prostate Cancer, Metastatic Castration-resistant Prostate CancerIntervention · Pembrolizumab, 177Lu-PSMA-617Updated Apr 2026
NCT03821792PHASE2ACTIVE_NOT_RECRUITING

Abiraterone Acetate, Prednisone, and Apalutamide in Treating Patients With Hormone-Naive Metastatic Prostate Cancer

Sponsor · M.D. Anderson Cancer CenterCondition · Metastatic Prostate Carcinoma, Prostate AdenocarcinomaIntervention · Abiraterone Acetate, ApalutamideUpdated Apr 2026
NCT07002320PHASE1, PHASE2RECRUITING

Investigating SX-682 in Combination With Apalutamide in Metastatic Castration-resistant Prostate Cancer

Sponsor · Institute of Cancer Research, United KingdomCondition · Metastatic Castrate-Resistant Prostate Cancer (mCRPC)Intervention · SX-682, ApalutamideUpdated Apr 2026
NCT05960578PHASE2ACTIVE_NOT_RECRUITING

Golimumab and Apalutamide for the Treatment of Castration-Resistant Prostate Cancer, TRAMP Study

Sponsor · University of WashingtonCondition · Metastatic Castration-Resistant Prostate Carcinoma, Prostate AdenocarcinomaIntervention · Apalutamide, BiopsyUpdated Apr 2026
NCT06592924PHASE3RECRUITING

Docetaxel to Androgen Receptor Pathway Inhibitors in Patients With Metastatic Castration Sensitive Prostate Cancer and Suboptimal PSA Response

Sponsor · Canadian Cancer Trials GroupCondition · Prostate Cancer (Adenocarcinoma)Intervention · Abiraterone, EnzalutamideUpdated Apr 2026
NCT06874114ACTIVE_NOT_RECRUITING

An Observational Study to Learn More About Treatment Patterns and Factors Determining the Choice of Treatment in Canadian Men With Metastatic Hormone Sensitive Prostate Cancer in Routine Medical Care

Sponsor · BayerCondition · Metastatic Hormone-sensitive Prostate CancerUpdated Apr 2026
NCT07406282RECRUITING

A Study to Learn About Real-world Utilization and Outcomes of Darolutamide and Other Androgen Receptor Pathway Inhibitors (ARPIs) for Newly Diagnosed Metastatic Hormone-sensitive Prostate Cancer (de Novo mHSPC) in US Urology Clinics

Sponsor · BayerCondition · Prostatic Neoplasms, Metastatic Hormone-Sensitive Prostate CancerIntervention · Darolutamide, Abiraterone acetateUpdated Apr 2026
NCT04787744PHASE2, PHASE3RECRUITING

Veterans Affairs Seamless Phase II/III Randomized Trial of STAndard Systemic theRapy With or Without PET-directed Local Therapy for Oligometastatic pRosTate Cancer

Sponsor · VA Office of Research and DevelopmentCondition · Prostate Cancer, OligometastasisIntervention · PET-directed Local Therapy using Surgery, PET-directed Local Therapy using RadiationUpdated Apr 2026
NCT06145308PHASE2RECRUITING

Precision Treatment of Recurrent/Metastatic Salivary Gland Carcinoma Guided by Molecular Typing

Sponsor · Peking Union Medical CollegeCondition · Salivary Gland Carcinoma, Precision TherapyIntervention · Cohort 1 (HER2-positive, RC48-ADC), Cohort 2 (NTRK-fusion or NTRK-mutant)Updated Apr 2026
NCT06734130PHASE2ACTIVE_NOT_RECRUITING

Adaptive Androgen Deprivation and Docetaxel in Metastatic Castration Sensitive Prostate Cancer

Sponsor · H. Lee Moffitt Cancer Center and Research InstituteCondition · Metastatic Castration Sensitive Prostate CancerIntervention · Luteinizing Hormone-Releasing Hormone (LHRH) analog, Androgen Receptor Signal Inhibitor (ARSI)Updated Apr 2026
NCT06832774PHASE2RECRUITING

Exploration of Treatment Effect of Novel Hormone Therapy Combined With Local Treatment Based on PSMA PET/CT Evaluation in mHSCP Patients

Sponsor · Shanghai General Hospital, Shanghai Jiao Tong University School of MedicineCondition · Prostate Cancer Metastatic DiseaseIntervention · Local treatment, Gonadotropin releasing hormone analog (GnRHa) + Novel hormone therapy (abiraterone, apalutamide or rezvilutamide).Updated Mar 2026
NCT03412396PHASE2ACTIVE_NOT_RECRUITING

Apalutamide in Treating Patients With Prostate Cancer Before Radical Prostatectomy

Sponsor · M.D. Anderson Cancer CenterCondition · Prostate Adenocarcinoma, Stage IIB Prostate Cancer AJCC v8Intervention · Apalutamide, Quality-of-Life AssessmentUpdated Mar 2026
NCT05751941PHASE2RECRUITING

Study of Sipuleucel-T With or Without Continuing New Hormonal Agents in Metastatic Prostate Cancer

Sponsor · H. Lee Moffitt Cancer Center and Research InstituteCondition · Prostate Cancer, Metastatic Prostate CancerIntervention · Abiraterone, EnzalutamideUpdated Mar 2026
NCT05884398PHASE3ACTIVE_NOT_RECRUITING

A Study of an Intermittent ADT Approach With Apalutamide Monotherapy in Participants With mCSPC

Sponsor · Janssen Research & Development, LLCCondition · Metastatic Castrate-sensitive Prostate CancerIntervention · Apalutamide, Androgen-deprivation Therapy (ADT)Updated Mar 2026
NCT07182279PHASE1, PHASE2RECRUITING

Neoadjuvant High Dose Rate Brachytherapy Prior to Radical Prostatectomy in Patients With Prostate Cancer

Sponsor · The Methodist Hospital Research InstituteCondition · Prostate Cancer (Adenocarcinoma)Intervention · BrachytherapyUpdated Mar 2026
NCT02703623PHASE2ACTIVE_NOT_RECRUITING

Abiraterone Acetate, Prednisone, and Apalutamide With or Without Ipilimumab or Cabazitaxel and Carboplatin in Treating Patients With Metastatic Castration-Resistant Prostate Cancer

Sponsor · M.D. Anderson Cancer CenterCondition · Castration Levels of Testosterone, Castration-Resistant Prostate CarcinomaIntervention · Abiraterone Acetate, ApalutamideUpdated Mar 2026
NCT05683964EARLY_PHASE1ACTIVE_NOT_RECRUITING

Androgen Receptor Signaling and Prostate-Specific Membrane Antigen Expression

Sponsor · Beth Israel Deaconess Medical CenterCondition · Prostate Adenocarcinoma, Prostate CancerIntervention · Apalutamide [Erleada], darolutamide [Nubeqa], or enzalutamide [Xtandi], Prostate-Specific Membrane Antigen (PSMA) PET/CT ScanUpdated Feb 2026
NCT07333066PHASE3NOT_YET_RECRUITING

Phase III Randomized International Open Label Clinical Trial of Treatment Intensification With Docetaxel Plus Apalutamide in Patients With Metastatic Hormone-sensitive Prostate Cancer Who Did Not Achieve a Deep PSA Response After Initial Treatment With Apalutamide: REINFORCE Trial.

Sponsor · Alianza multidisciplinar para la investigación de los tumores genitourinarios -GUARDCondition · Metastatic Hormone-sensitive Prostate CancerIntervention · Apalutamide (Erleada™) 60 mg or 240 mg tablets, DocetaxelUpdated Jan 2026
NCT05413421PHASE1RECRUITING

Study of ORIC-944 in Patients With Metastatic Prostate Cancer

Sponsor · ORIC PharmaceuticalsCondition · Metastatic Prostate CancerIntervention · ORIC-944, Abiraterone acetate (Zytiga®) 250 mg or 500 mg tabletsUpdated Aug 2025
NCT04523207PHASE2COMPLETED

A Study of Apalutamide (Adjuvant Treatment) and Androgen Deprivation Therapy (ADT) in Participants Who Have Undergone Radical Prostatectomy (RP) for Non-metastatic Prostate Cancer and Who Are at High Risk for Metastases

Sponsor · Janssen Research & Development, LLCCondition · Prostatic NeoplasmsIntervention · Apalutamide, ADTUpdated Apr 2026
NCT02913196PHASE1COMPLETED

Phase I Trial of Apalutamide Plus Abiraterone Acetate, Docetaxel, and Prednisone in Patients With mCRPC

Sponsor · Weill Medical College of Cornell UniversityCondition · Prostate Cancer MetastaticIntervention · Apalutamide, Abiraterone acetateUpdated Apr 2026
NCT02772588PHASE2COMPLETED

AASUR in High Risk Prostate Cancer

Sponsor · Memorial Sloan Kettering Cancer CenterCondition · Prostate CancerIntervention · ARN-509, AbirateroneUpdated Apr 2026
NCT03088124PHASE2COMPLETED

Active Surveillance With or Without Apalutamide Treatment in Low Risk Prostate Cancer

Sponsor · Institut Paoli-CalmettesCondition · Low Risk Prostate CancerIntervention · ApalutamideUpdated Mar 2026
NCT07477756COMPLETED

A Real-world Study of Characteristics, Treatment Patterns, and Clinical Outcomes Among Lutetium-177 Vipivotide Tetraxetan Treated Patients

Sponsor · Novartis PharmaceuticalsCondition · Prostate CancerUpdated Mar 2026
NCT07428642COMPLETED

PSMA PET/CT-Based Multimodal Model for Predicting Response to First-Line Therapy in mHSPC.

Sponsor · First Affiliated Hospital of Wenzhou Medical UniversityCondition · Metastatic Hormone-Sensitive Prostate Cancer, Prostate CancerIntervention · Androgen Deprivation Therapy, ApalutamideUpdated Mar 2026
NCT03360721PHASE2TERMINATED

Apalutamide, Abiraterone Acetate, and Prednisone in Treating Participants With Metastatic Castration Resistant Prostate Cancer

Sponsor · M.D. Anderson Cancer CenterCondition · Castration-Resistant Prostate Carcinoma, Prostate Adenocarcinoma Without Neuroendocrine DifferentiationIntervention · Abiraterone Acetate, ApalutamideUpdated Mar 2026
NCT04179864PHASE1, PHASE2TERMINATED

A Study of Tazemetostat With Enzalutamide or Abiraterone/Prednisone in Participants With Advanced Prostate Cancer

Sponsor · Epizyme, Inc.Condition · Metastatic Prostate Cancer, Metastatic Castration-resistant Prostate CancerIntervention · Tazemetostat, Abiraterone/prednisoneUpdated Mar 2026
NCT04104893PHASE2ACTIVE_NOT_RECRUITING

A Study of CHeckpoint Inhibitors in Men With prOgressive Metastatic Castrate Resistant Prostate Cancer Characterized by a Mismatch Repair Deficiency or Biallelic CDK12 Inactivation

Sponsor · VA Office of Research and DevelopmentCondition · Metastatic Castration Resistant Prostate CancerIntervention · PembrolizumabUpdated Feb 2026
NCT07089550RECRUITING

PSMA PET for Treatment Response evaLuation of systemIC Therapies in prostAte caNcer (PELICAN)

Sponsor · IRCCS Azienda Ospedaliero-Universitaria di BolognaCondition · PSMA Positive Tumors or Tumor Tissues, Prostate Cancer MetastaticIntervention · PSMA PET/CT scanUpdated Feb 2026
NCT05647564NARECRUITING

PET/CT Characterization of Treatment Resistance

Sponsor · University of Wisconsin, MadisonCondition · Prostate CancerIntervention · F-fluorodeoxyglucose positron emission tomography (FDG PET), prostate-specific membrane antigen positron emission tomography (PSMA PET)Updated Feb 2026
NCT04478279PHASE1, PHASE2ACTIVE_NOT_RECRUITING

A Phase 1-2 Study of ST101 in Patients With Advanced Solid Tumors

Sponsor · Sapience TherapeuticsCondition · Glioblastoma, Melanoma Stage IVIntervention · ST101, TemozolomideUpdated Feb 2026
NCT04704505PHASE2RECRUITING

Bipolar Androgen Therapy (BAT) and Radium-223 (RAD) in Metastatic Castration-resistant Prostate Cancer (mCRPC)

Sponsor · Sidney Kimmel Comprehensive Cancer Center at Johns HopkinsCondition · Prostate Adenocarcinoma, Metastatic Prostate AdenocarcinomaIntervention · radium-223, Bipolar Androgen Therapy (BAT)Updated Feb 2026
NCT03902951PHASE2ACTIVE_NOT_RECRUITING

Antiandrogen Therapy and SBRT in Treating Patients With Recurrent, Metastatic Prostate Cancer

Sponsor · Jonsson Comprehensive Cancer CenterCondition · Metastatic Prostate Adenocarcinoma, Prostate Adenocarcinoma With Focal Neuroendocrine DifferentiationIntervention · Abiraterone Acetate, ApalutamideUpdated Feb 2026
NCT07389174EARLY_PHASE1NOT_YET_RECRUITING

Safety and Efficacy Evaluation of LC-K76 in Patients With Metastatic Hormone-Sensitive Prostate Cancer

Sponsor · Shanghai Changzheng HospitalCondition · mHSPC, mHNPCIntervention · Standard Endocrine Therapy, LC-K76Updated Feb 2026
NCT04729114PHASE1RECRUITING

A Safety and Dose-finding Study of PRL-02 Depot in Men With Advanced Prostate Cancer

Sponsor · Astellas Pharma Global Development, Inc.Condition · Prostate Cancer, Metastatic Castration Resistant Prostate CancerIntervention · PRL-02 injection, prednisoneUpdated Feb 2026
NCT05534646PHASE2RECRUITING

Study of Apalutamide With Carotuximab in Metastatic, Castration-Resistant Prostate Cancer

Sponsor · Edwin Posadas, MDCondition · Castration-resistant Prostate CancerIntervention · Apalutamide, CarotuximabUpdated Feb 2026
NCT07344363RECRUITING

Prostate Cancer REsearch Using Cross-validation of Innovative Sampling, Integrating LC-MS/MS for Optimized Therapeutic Drug moNitoring

Sponsor · Centro di Riferimento Oncologico - AvianoCondition · Prostate CancerUpdated Feb 2026
NCT04267887PHASE2ACTIVE_NOT_RECRUITING

Advanced ChemoHormonal Therapy for Treatment Naive Metastatic Prostate Cancer

Sponsor · OHSU Knight Cancer InstituteCondition · Castration-Sensitive Prostate Carcinoma, Metastatic Prostate CarcinomaIntervention · Abiraterone Acetate, Antiandrogen TherapyUpdated Jan 2026
NCT03371719PHASE2ACTIVE_NOT_RECRUITING

Radiation Therapy With or Without Apalutamide in Treating Patients With Recurrent Prostate Cancer, the BALANCE Trial

Sponsor · NRG OncologyCondition · Recurrent Prostate Carcinoma, Stage III Prostate Adenocarcinoma AJCC v7Intervention · Apalutamide, External Beam Radiation TherapyUpdated Jan 2026
NCT02949284PHASE2ACTIVE_NOT_RECRUITING

Androgen Receptor Antagonist ARN-509 With or Without Abiraterone Acetate, Gonadotropin-Releasing Hormone Analog, and Prednisone in Treating Patients With High-Risk Prostate Cancer Undergoing Surgery

Sponsor · Rutgers, The State University of New JerseyCondition · Stage II Prostate Adenocarcinoma, Stage III Prostate AdenocarcinomaIntervention · Abiraterone Acetate, Androgen Receptor Antagonist ARN-509Updated Jan 2026
NCT05241860PHASE2ACTIVE_NOT_RECRUITING

Testing Interruption of Hormonal Medications in Patients Responding Exceptionally to Therapy for Metastatic Prostate Cancer, (A-DREAM)

Sponsor · Alliance for Clinical Trials in OncologyCondition · Castration-Sensitive Prostate Carcinoma, Metastatic Prostate CarcinomaIntervention · Pharmacotherapy Discontinuation, Follow-UpUpdated Dec 2025
NCT07268794PHASE2NOT_YET_RECRUITING

CONVERT-HB1: Radical Prostatectomy After Systemic Therapy for High-volume Metastatic Hormone-sensitive Prostate Cancer

Sponsor · Fudan UniversityCondition · Metastatic Prostate Cancer, Prostate Cancer (Adenocarcinoma)Intervention · Androgen Deprivation Therapy (ADT), DocetaxelUpdated Dec 2025
NCT05367440PHASE1, PHASE2ACTIVE_NOT_RECRUITING

Study of AZD5305 When Given in Combination With New Hormonal Agents in Patients With Metastatic Prostate Cancer

Sponsor · AstraZenecaCondition · Metastatic Prostate CancerIntervention · AZD5305, EnzalutamideUpdated Dec 2025
NCT05189457PHASE2ACTIVE_NOT_RECRUITING

First Strike, Second Strike Therapies for High Risk Metastatic Castration Sensitive Prostate Cancer

Sponsor · H. Lee Moffitt Cancer Center and Research InstituteCondition · Prostate Cancer, Stage IV Prostate CancerIntervention · Luteinizing Hormone Releasing Hormone, New Hormonal AgentUpdated Dec 2025
NCT07260435PHASE3RECRUITING

Apa/Enza-short Study: Shorter Treatment With Androgen Receptor Pathway Inhibitor in Patients With Low-volume Metastatic Castration-sensitive Prostate Cancer

Sponsor · Nick BeijeCondition · Prostate CancerIntervention · ADT plus only 12 months of ARPI, ADT plus continued ARPIUpdated Dec 2025
NCT07197697PHASE2NOT_YET_RECRUITING

A Phase II Exploratory Study of Iparomlimab and Tuvonralimab Combined With Chemotherapy in Neoadjuvant Treatment of HR+/HER2- Breast Cancer Patients

Sponsor · Anhui Provincial Cancer HospitalCondition · Breast CancerIntervention · Iparomlimab and Tuvonralimab Injection (QL1706) combined chemotherapyUpdated Sep 2025
NCT06320067PHASE3RECRUITING

A Randomised Controlled Platform Trial Testing Treatments in Metastatic Hormone Sensitive Prostate Cancer

Sponsor · University College, LondonCondition · Prostate Cancer MetastaticIntervention · Stereotactic Ablative Body Radiotherapy (SABR), 177Lu-PSMA-617Updated Sep 2025
NCT05974774PHASE3RECRUITING

Intermittent Androgen Deprivation Therapy in the Era of AR Pathway Inhibitors

Sponsor · European Organisation for Research and Treatment of Cancer - EORTCCondition · Prostate CancerIntervention · iMAB, cMABUpdated Sep 2025
NCT06019676ACTIVE_NOT_RECRUITING

Impact of Apalutamide in Metastatic Hormone Sensitive Prostate Cancer Patients

Sponsor · Royal Marsden NHS Foundation TrustCondition · Metastatic Hormone-Sensitive Prostate Cancer (mHSPC)Updated Sep 2025
NCT07172217PHASE2NOT_YET_RECRUITING

The Efficacy and Safety RC48 Plus QL1706 in Second-Line Treatment of HER2-Expressing Recurrent CC

Sponsor · Qilu Hospital of Shandong UniversityCondition · Recurrent Cervical CancerIntervention · RC48, QL1706Updated Sep 2025
NCT07154914NOT_YET_RECRUITING

A Novel Insight Into CRPC Progression and Immune: Evidence From Single-cell Spatial Transcriptome Multi-omics

Sponsor · Anhui Medical UniversityCondition · Metastatic Hormone-Sensitive Prostate CanceIntervention · Abiraterone + ADTUpdated Sep 2025
NCT05649943NARECRUITING

Multimodal Approach in Patients With mHSPC. Randomized Trial of APA+ADT vs APA-ADT and Local Treatment

Sponsor · Fondazione IRCCS Istituto Nazionale dei Tumori, MilanoCondition · Metastatic Hormone-Sensitive Prostate Cancer (mHSPC)Intervention · APA + ADT, Local Treatmetn RT or RPUpdated Sep 2025
NCT03170960PHASE1ACTIVE_NOT_RECRUITING

Study of Cabozantinib Alone or in Combination With Atezolizumab to Subjects With Locally Advanced or Metastatic Solid Tumors

Sponsor · ExelixisCondition · Urothelial Carcinoma, Renal Cell CarcinomaIntervention · cabozantinib, atezolizumabUpdated Aug 2025
NCT04181203PHASE3ACTIVE_NOT_RECRUITING

Combined Apalutamide, Radiotherapy, and LHRH Agonist in Prostate Cancer Patients After Prostatectomy

Sponsor · UNICANCERCondition · Prostate CancerIntervention · Apalutamide, Salvage radiotherapy (SRT)Updated Jul 2025
NCT05551117PHASE2TERMINATED

A Study of Vobramitamab Duocarmazine in Participants With Metastatic Castration Resistant Prostate Cancer and Other Solid Tumors

Sponsor · MacroGenicsCondition · Castration-Resistant Prostatic Cancer, Androgen-Independent Prostatic CancerIntervention · vobramitamab duocarmazine 2.0 mg (Arm A), vobramitamab duocarmazine 2.7 mg (Arm B)Updated Feb 2026
NCT05701007COMPLETED

Real World Evidence Study on Metastatic Prostate Cancer in the Pirkanmaa Hospital District in Finland

Sponsor · PfizerCondition · Metastatic Castration Sensitive Prostate Cancer (mCSPC), Metastatic Castration Resistant Prostate Cancer (mCRPC)Intervention · abiraterone, enzalutamideUpdated Jan 2026
NCT03503344PHASE2COMPLETED

Apalutamide With or Without Stereotactic Body Radiation in Treating Castration-Resistant Prostate Cancer

Sponsor · University of California, San FranciscoCondition · Castration Levels of Testosterone, Castration-Resistant Prostate CarcinomaIntervention · Apalutamide, Stereotactic Body Radiation TherapyUpdated Jan 2026
NCT06072196COMPLETED

A Study to Learn About Novel Hormonal Therapies in People With Metastatic Castration-Sensitive Prostate Cancer (mCSPC)

Sponsor · PfizerCondition · Prostatic NeoplasmsIntervention · Novel hormonal therapyUpdated Dec 2025
NCT03009981PHASE3COMPLETED

A Study of Androgen Annihilation in High-Risk Biochemically Relapsed Prostate Cancer

Sponsor · Alliance Foundation Trials, LLC.Condition · Prostate CancerIntervention · Apalutamide, LHRH AnalogueUpdated Dec 2025
NCT04034095COMPLETED

A Registry Study to Observe Clinical Outcomes of Participants With High-risk Metastatic Hormone-naïve Prostate Cancer in Japan

Sponsor · Janssen Pharmaceutical K.K.Condition · Prostatic NeoplasmsIntervention · Androgen-deprivation Therapy (ADT), BicalutamideUpdated Dec 2025
NCT03523338NO_LONGER_AVAILABLE

An Expanded Access Protocol for Apalutamide Treatment of Participants With Non-Metastatic Castration-Resistant Prostate Cancer

Sponsor · Aragon Pharmaceuticals, Inc.Condition · Prostatic NeoplasmsIntervention · Apalutamide, ADT (Standard of Care)Updated Dec 2025
NCT07086651COMPLETED

A Study to Learn About Two Medicines (Apalutamide and Enzalutamide) in People With Metastatic Castration-sensitive Prostate Cancer (mCSPC)

Sponsor · PfizerCondition · Metastatic Castration Sensitive Prostate Cancer (mCSPC), Cancer of the ProstateIntervention · Enzalutamide, ApalutamideUpdated Dec 2025
NCT03098836PHASE2COMPLETED

Apalutamide and Abiraterone Acetate in African American and Caucasian Men With Metastatic Castrate Resistant Prostate Cancer

Sponsor · Daniel George, MDCondition · Prostate CancerIntervention · ARN-509, Abiraterone AcetateUpdated Sep 2025
NCT04666129PHASE1COMPLETED

Study of Relugolix in Men With Metastatic Castration-Sensitive Prostate Cancer or Non-Metastatic or Metastatic Castration-Resistant Prostate Cancer

Sponsor · Sumitomo Pharma America, Inc.Condition · Metastatic Castration-Resistant Prostate Cancer, Metastatic Castration-Sensitive Prostate CancerIntervention · Relugolix, AbirateroneUpdated Aug 2025
NCT05202301COMPLETED

A Study Using Available Data to Learn to What Extent Patients With Prostate Cancer Who Received Second Generation Androgen Receptor Inhibitors Took Their Medication as Prescribed or Stopped Taking Their Medication Completely

Sponsor · BayerCondition · Prostate CancerIntervention · Darolutamide (Nubeqa, BAY1841788), EnzalutamideUpdated Aug 2025
NCT03298087PHASE2COMPLETED

Systemic and Tumor-Directed Therapy for Oligometastatic Prostate Cancer

Sponsor · VA Office of Research and DevelopmentCondition · Newly Diagnosed Oligometastatic Prostate CancerIntervention · radical prostatectomy, stereotactic body radiotherapyUpdated Aug 2025
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