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Mezigdomide

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Bristol-Myers Squibb

CELMoD agent (cereblon E3 ligase modulator) developed as a next-generation successor to lenalidomide and pomalidomide, with enhanced cereblon binding designed t

Relapsed or Refractory Multiple Myeloma

Studies (24 shown)

NCT06988488PHASE1, PHASE2RECRUITING

A Study to Determine the Recommended Dose and Schedule, and Evaluate the Safety and Preliminary Efficacy of Mezigdomide in Combination With Elranatamab in Participants With Relapsed and/or Refractory Multiple Myeloma

Sponsor · CelgeneCondition · Multiple MyelomaIntervention · Elranatamab, MezigdomideUpdated May 2026
NCT05519085PHASE3RECRUITING

A Study to Evaluate Mezigdomide, Bortezomib and Dexamethasone (MEZIVd) Versus Pomalidomide, Bortezomib and Dexamethasone (PVd) in Participants With Relapsed or Refractory Multiple Myeloma (RRMM)

Sponsor · CelgeneCondition · Relapsed or Refractory Multiple MyelomaIntervention · mezigdomide, PomalidomideUpdated May 2026
NCT07032714PHASE1RECRUITING

Mezigdomide and Talquetamab in Relapsed and Refractory Multiple Myeloma

Sponsor · Massachusetts General HospitalCondition · Relapsed Refractory Multiple Myeloma (RRMM)Intervention · Talquetamab, MezigdomideUpdated Apr 2026
NCT06048250PHASE1RECRUITING

Mezigdomide (CC-92480) Post Idecabtagene Vicleucel in Treating Patients With Relapsed Multiple Myeloma

Sponsor · City of Hope Medical CenterCondition · Multiple MyelomaIntervention · Biospecimen Collection, Bone Marrow AspirationUpdated Apr 2026
NCT05552976PHASE3ACTIVE_NOT_RECRUITING

A Study to Evaluate Mezigdomide in Combination With Carfilzomib and Dexamethasone (MeziKD) Versus Carfilzomib and Dexamethasone (Kd) in Participants With Relapsed or Refractory Multiple Myeloma (SUCCESSOR-2)

Sponsor · Bristol-Myers SquibbCondition · Relapsed or Refractory Multiple MyelomaIntervention · Mezigdomide, CarfilzomibUpdated Apr 2026
NCT06163898PHASE1TERMINATED

A Study to Evaluate Alnuctamab in Combination With Mezigdomide in Participants With Relapsed and/or Refractory Multiple Myeloma

Sponsor · CelgeneCondition · Multiple MyelomaIntervention · Alnuctamab, MezigdomideUpdated Apr 2026
NCT07105059PHASE1RECRUITING

A Study of Teclistamab and Mezigdomide in People With Multiple Myeloma

Sponsor · Memorial Sloan Kettering Cancer CenterCondition · Multiple MyelomaIntervention · Teclistamab, MezigdomideUpdated Feb 2026
NCT07355335PHASE1NOT_YET_RECRUITING

Ziftomenib + Mezigdomide in Adolesc. and Adults w/ R/R AML

Sponsor · Massachusetts General HospitalCondition · KMT2A-rearranged, NPM1-mutant Refractory or Relapsed AMLIntervention · Ziftomenib, MezigdomideUpdated Jan 2026
NCT07356154PHASE1, PHASE2RECRUITING

A Study of Revumenib and Mezigdomide in People With Leukemia

Sponsor · Memorial Sloan Kettering Cancer CenterCondition · Leukemia, Acute LeukemiaIntervention · Revumenib, MezigdomideUpdated Jan 2026
NCT06627751PHASE2RECRUITING

Mezigdomide, Carfilzomib, and Dexamethasone for the Treatment of Relapsed or Refractory Multiple Myeloma in Patients With Extramedullary Disease

Sponsor · Roswell Park Cancer InstituteCondition · Extramedullary Disease in Multiple Myeloma, Recurrent Multiple MyelomaIntervention · Mezigdomide, CarfilzomibUpdated Jan 2026
NCT06645678PHASE1, PHASE2RECRUITING

Mezigdomide and Elranatamab for Relapsed and/or Refractory Multiple Myeloma

Sponsor · YOUNGIL KOHCondition · Relapsed Refractory Multiple Myeloma (RRMM)Intervention · Elranatamab, MezigdomideUpdated Dec 2025
NCT06994117AVAILABLE

Expanded Access for Mezigdomide

Sponsor · Bristol-Myers SquibbIntervention · MezigdomideUpdated Dec 2025
NCT06318676PHASE1COMPLETED

A Study to Evaluate the Drug Levels of Mezigdomide in Adult Participants With Renal Impairment

Sponsor · CelgeneCondition · Renal ImpairmentIntervention · MezigdomideUpdated Jun 2025
NCT06050512PHASE1, PHASE2WITHDRAWN

Mezigdomide Plus Ixazomib and Dexamethasone for Relapsed and Refractory Multiple Myeloma

Sponsor · Kathleen DorritieCondition · Relapsed and Refractory Multiple MyelomaIntervention · Mezigdomide, IxazomibUpdated Nov 2024
NCT05707390PHASE1COMPLETED

A Study of Mezigdomide in Healthy Participants and Participants With Hepatic Impairment

Sponsor · Bristol-Myers SquibbCondition · Hepatic ImpairmentIntervention · MezigdomideUpdated Feb 2024
NCT06121843PHASE1RECRUITING

A Study to Evaluate the Safety, Effectiveness and Tolerable Dose of Arlocabtagene Autoleucel (BMS-986393) in Novel Combinations in Participants With Relapsed and/or Refractory Multiple Myeloma

Sponsor · Juno Therapeutics, Inc., a Bristol-Myers Squibb CompanyCondition · Multiple MyelomaIntervention · BMS-986393, AlnuctamabUpdated Feb 2026
NCT05651932PHASE1RECRUITING

A Study of an MMSET Inhibitor in Patients With Relapsed and Refractory Multiple Myeloma

Sponsor · K36 Therapeutics, Inc.Condition · Multiple Myeloma, MyelomaIntervention · Cohort A1 & A2: KTX-1001, Cohort B1 & B2: KTX-1001+MezigdomideUpdated Feb 2026
NCT07612787PHASE2NOT_YET_RECRUITING

A Multicenter Study of Belantamab Mafodotin and Mezigdomide in Patients With Relapsed Multiple Myeloma

Sponsor · Centre Hospitalier Universitaire de Saint EtienneCondition · Myeloma MultipleIntervention · CAR-T cells, BCMA bispecificUpdated May 2026
NCT07348393PHASE2NOT_YET_RECRUITING

A Phase 2, Single Arm Multicenter, Study Testing Mezigdomide, Carfilzomib, and Dexamethasone (480Kd) in Participants With Relapsed or Refractory Multiple Myeloma (RRMM)

Sponsor · Assistance Publique - Hôpitaux de ParisCondition · Relapsed or Refractory Multiple Myeloma (RRMM)Intervention · Administration of a combination of treatmentsUpdated Jan 2026
NCT05539976COMPLETED

A Taste Assessment of Iberdomide and Mezigdomide in Healthy Participants

Sponsor · Bristol-Myers SquibbCondition · Healthy ParticipantsUpdated Dec 2022
NCT05981209PHASE1ACTIVE_NOT_RECRUITING

Elotuzumab, CC-92480, and Dexamethasone for the Treatment of Relapsed or Refractory Myeloma After CD38- and BCMA-Targeted Therapies

Sponsor · Abdullah KhanCondition · Recurrent Multiple Myeloma, Refractory Multiple MyelomaIntervention · Biospecimen Collection, Bone Marrow AspirationUpdated May 2026
NCT02343042PHASE1, PHASE2ACTIVE_NOT_RECRUITING

Selinexor and Backbone Treatments of Multiple Myeloma Patients

Sponsor · Karyopharm Therapeutics IncCondition · Multiple MyelomaIntervention · Selinexor, DexamethasoneUpdated May 2026
NCT03989414PHASE1, PHASE2ACTIVE_NOT_RECRUITING

A Study to Determine the Recommended Dose and Regimen and to Evaluate the Safety and Preliminary Efficacy of CC-92480 in Combination With Standard Treatments in Participants With Relapsed or Refractory Multiple Myeloma (RRMM) and Newly Diagnosed Multiple Myeloma (NDMM)

Sponsor · CelgeneCondition · Multiple MyelomaIntervention · CC-92480, BortezomibUpdated Nov 2024
NCT03374085PHASE1, PHASE2TERMINATED

A Safety, PK and Efficacy Study of CC-92480 Monotherapy and in Combination With Dexamethasone in Subjects With Relapsed and Refractory Multiple Myeloma (RRMM)

Sponsor · CelgeneCondition · Multiple MyelomaIntervention · CC-92480, DexamethasoneUpdated Feb 2026
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