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Ivonescimab

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Summit Therapeutics / Akeso

PD-1 × VEGF bispecific antibody. HARMONi-3 (NCT05899608) is the pivotal global Phase 3: ivonescimab + chemo vs pembrolizumab + chemo in 1L metastatic NSCLC (all

NSCLCEGFR-mutant2L+

Studies (100 shown)

NCT06940518PHASE2RECRUITING

Phase II Trial of Ivonescimab in Previously Treated Patients With Advanced Clear Cell Renal Cell Carcinoma

Sponsor · M.D. Anderson Cancer CenterCondition · Ivonescimab, Clear Cell Renal CarcinomaIntervention · IvonescimabUpdated May 2026
NCT07614646PHASE1NOT_YET_RECRUITING

Evaluate the Safety, Tolerability, and Preliminary Efficacy of EVM14 in Combination With Ivonescimab in Sq-NSCLC Patients

Sponsor · Everest Medicines (Beijing) Co., Ltd.Condition · Squamous Non-Small Cell Lung Cancer sqNSCLCIntervention · EVM14, IvonescimabUpdated May 2026
NCT07602855PHASE1, PHASE2NOT_YET_RECRUITING

A Study of Risvutatug Rezetecan in Combination With Ivonescimab in Participants With Advanced Solid Tumors (EMBOLD PanTumour-103)

Sponsor · GlaxoSmithKlineCondition · Solid TumorsIntervention · Ris-Rez, IvonescimabUpdated May 2026
NCT07264075PHASE3RECRUITING

Study Comparing Ivonescimab Alone or Ivonescimab in Combination With Ligufalimab Versus Pembrolizumab for the Treatment of SCCHN

Sponsor · Groupe Oncologie Radiotherapie Tete et CouCondition · Squamous Cell Carcinoma Head and Neck Cancer (HNSCC)Intervention · Ivonescimab 10 mg/kg, LigufalimabUpdated May 2026
NCT06959550PHASE2RECRUITING

Phase II Study of Anti-PD-1/VEGF Bispecific Antibody Ivonescimab in Patients With Previously Treated Metastatic Colorectal Cancer

Sponsor · M.D. Anderson Cancer CenterCondition · Metastatic Colorectal CancerIntervention · IvonescimabUpdated May 2026
NCT06529718PHASE2RECRUITING

Testing Ivonescimab Versus FOLFOX in Advanced Biliary Tract Cancer Patients

Sponsor · UNICANCERCondition · Biliary Tract CancerIntervention · Ivonescimab, FOLFOX regimenUpdated May 2026
NCT07359456PHASE2NOT_YET_RECRUITING

Testing Ivonescimab in Combination With Chemotherapy in Patients With Metastatic Colorectal Cancers Without Liver Metastases

Sponsor · UNICANCERCondition · Metastatic Colorectal CancerIntervention · Ivonescimab, BevacizumabUpdated May 2026
NCT07594522PHASE1, PHASE2RECRUITING

A Study of Ivonescimab in People With Non-Small Cell Lung Cancer

Sponsor · Memorial Sloan Kettering Cancer CenterCondition · Non-Small Cell Lung CancerIntervention · Photon or Proton standard stereotactic body radiotherapy (SBRT), IvonescimabUpdated May 2026
NCT07057791PHASE2RECRUITING

Phase II Study of Platinum/Etoposide Plus Ivonescimab for Extensive-Stage Small Cell Lung Cancer

Sponsor · PrECOG, LLC.Condition · Extensive Stage Lung Small Cell CancerIntervention · Ivonescimab 10 mg/kg, Ivonescimab 20 mg/kgUpdated May 2026
NCT07397338PHASE1, PHASE2RECRUITING

Study of RAS(ON) Inhibitors in Combination With Ivonescimab in Patients With Solid Tumors

Sponsor · Revolution Medicines, Inc.Condition · Advanced Solid Tumors, Metastatic Solid TumorsIntervention · Daraxonrasib, ElironrasibUpdated May 2026
NCT07412262PHASE2NOT_YET_RECRUITING

A Study of Chidamide Combined With Ivonescimab in the Treatment of Advanced Non-Small Cell Lung Cancer (NSCLC) With Acquired Resistance to Immunotherapy and High Yes-associated Protein (YAP) Expression

Sponsor · Guangdong Association of Clinical TrialsCondition · Non-Small Cell Lung CancerIntervention · Chidamide in combination with IvonescimabUpdated May 2026
NCT07228832PHASE3RECRUITING

Phase III Study of Ivonescimab or Bevacizumab Combined With FOLFOX in Patients With Metastatic Colorectal Cancer

Sponsor · Summit TherapeuticsCondition · Metastatic Colorectal Cancer (CRC)Intervention · Drug: Ivonescimab Injection, Drug: Bevacizumab InjectionUpdated May 2026
NCT07565389PHASE2NOT_YET_RECRUITING

Evaluating Ivonescimab in PD-1 Resistant Recurrent or Metastatic Nasopharyngeal Carcinoma

Sponsor · National University Hospital, SingaporeCondition · Nasopharyngeal Carcinoma (NPC)Intervention · Ivonescimab 20 mg/kgUpdated May 2026
NCT07560124PHASE1, PHASE2NOT_YET_RECRUITING

A Study of AK138D1 Alone or in Combination With Ivonescimab in Advanced Breast Cancer

Sponsor · AkesoCondition · Breast CancerIntervention · AK138D1, IvonescimabUpdated Apr 2026
NCT05899608PHASE3RECRUITING

Clinical Study of Ivonescimab for First-line Treatment of Metastatic NSCLC Patients

Sponsor · Summit TherapeuticsCondition · Non-Small Cell Lung CancerIntervention · Ivonescimab Injection, Pembrolizumab InjectionUpdated Apr 2026
NCT06844422PHASE1, PHASE2RECRUITING

Adapted Guided Stereotactic Body Radiotherapy Combined With Chemotherapy and Enhancement of Novel Drug Ivonescimab for Pancreatic Cancer (ASCEND)

Sponsor · Shandong Cancer Hospital and InstituteCondition · Pancreatic CancerIntervention · IvonescimabUpdated Apr 2026
NCT06846346PHASE2RECRUITING

Testing Ivonescimab in Combination With Chemotherapy in Advanced or Metastatic Gastric/Gastroesophageal Adenocarcinoma

Sponsor · UNICANCERCondition · Metastatic Esophageal Adenocarcinoma, Advanced Esophageal AdenocarcinomaIntervention · Ivonescimab, FOLFOX regimenUpdated Apr 2026
NCT07244978PHASE2NOT_YET_RECRUITING

Neoadjuvant Ivonescimab(AK112) Combined With Chemotherapy in Patients With Resectable Esophageal Squamous Cell Carcinoma

Sponsor · Second Affiliated Hospital, School of Medicine, Zhejiang UniversityCondition · Esophageal Squamous Cell Carcinoma, Neoadjuvant TherapyIntervention · Ivonescimab(AK112), Albumin paclitaxel, carboplatin AUC=5, neoadjuvant therapy, EsophagectomyUpdated Apr 2026
NCT07535437PHASE1, PHASE2RECRUITING

A Study of Ivonescimab in Combination With Dato-DXd or Osimertinib in People With Non-Small Cell Lung Cancer

Sponsor · Memorial Sloan Kettering Cancer CenterCondition · Non-Small Cell Lung CancerIntervention · Ivonescimab, Dato-DXdUpdated Apr 2026
NCT07158489PHASE2NOT_YET_RECRUITING

Overcoming Resistance to Immunotherapy Combining Gemcitabine With Ivonescimab in Advanced NSCLC

Sponsor · Swiss Cancer InstituteCondition · NSCLC, NSCLC (Advanced Non-small Cell Lung Cancer)Intervention · Gemcitabine + IvonescimabUpdated Apr 2026
NCT06567314PHASE2RECRUITING

Phase 2 Study of Ivonescimab in Patients With Cutaneous Squamous Cell Carcinoma

Sponsor · M.D. Anderson Cancer CenterCondition · Cutaneous Squamous Cell CarcinomaIntervention · IvonescimabUpdated Apr 2026
NCT07535463PHASE1, PHASE2RECRUITING

A Study of Ivonescimab, Chemotherapy, and Stereotactic Radiosurgery for People With Non-Small Cell Lung Cancer

Sponsor · Memorial Sloan Kettering Cancer CenterCondition · Non-Small Cell Lung CancerIntervention · Ivonescimab, Stereotactic RadiosurgeryUpdated Apr 2026
NCT06928389PHASE3RECRUITING

Ivonescimab in Combination With Docetaxel in Advanced Non-Small Cell Lung Cancer

Sponsor · AkesoCondition · Non-Small Cell Lung CancerIntervention · Ivonescimab, docetaxel, Placebo, docetaxelUpdated Apr 2026
NCT07516925PHASE2RECRUITING

A Study of Ivonescimab in People With Leiomyosarcoma

Sponsor · Memorial Sloan Kettering Cancer CenterCondition · LeiomyosarcomaIntervention · IvonescimabUpdated Apr 2026
NCT07017673PHASE2RECRUITING

Phase II Trial of Ivonescimab in Combination With Carboplatin + Docetaxel in Patients With Early-Stage Triple Negative Breast Cancer

Sponsor · Cedars-Sinai Medical CenterCondition · TNBC, TNBC - Triple-Negative Breast CancerIntervention · Ivonescimab, CarboplatinUpdated Apr 2026
NCT06925724PHASE2RECRUITING

A Study of Ivonescimab in People With Endometrial and Cervical Cancers

Sponsor · Memorial Sloan Kettering Cancer CenterCondition · Endometrial Cancer, Cervical CancerIntervention · IvonescimabUpdated Mar 2026
NCT07472478PHASE2NOT_YET_RECRUITING

Phase II Neoadjuvant Study of Garsorasib Followed by Ivonescimab Plus Chemotherapy in Resectable Stage IIA-IIIB KRAS G12C-Mutant NSCLC (GIVEN Study)

Sponsor · Guangdong Provincial People's HospitalCondition · Lung Cancer (NSCLC), KRAS G12C Lung CancerIntervention · Garsorasib, Ivonescimab Combined With ChemotherapyUpdated Mar 2026
NCT06840834PHASE2RECRUITING

Evaluating Ivonescimab as a Potential Treatment for Pleural Mesothelioma Patients Whose Cancer Has Returned After Previous Immunotherapy and Chemotherapy

Sponsor · Intergroupe Francophone de Cancerologie ThoraciqueCondition · Pleural MesotheliomasIntervention · IvonescimabUpdated Mar 2026
NCT07359040ACTIVE_NOT_RECRUITING

Mechanism of Enhanced Efficacy of Ivonescimab in Neoadjuvant Therapy for Non-Small Cell Lung Cancer

Sponsor · Peking University People's HospitalCondition · Non-Small Cell Lung Cancer, Neoadjuvant TherapyIntervention · Ivonescimab, PD-1 InhibitorsUpdated Mar 2026
NCT06951646PHASE2RECRUITING

ctDNA-MRD Guided Escalation of Ivonescimab and Docetaxel in Advanced NSCLC With Long-Term Responses to First-line Immunotherapy (CR1STAL-Adaptive)

Sponsor · Second Xiangya Hospital of Central South UniversityCondition · Non Small Cell Lung Cancer, Immune Checkpoint Inhibitors (ICIs)Intervention · Ivonescimab, DocetaxelUpdated Mar 2026
NCT07070466PHASE2RECRUITING

Ivonescimab in Comb. With FOLFOX in Advanced HER2 Neg. GEA

Sponsor · Massachusetts General HospitalCondition · Stomach Cancer Stage IV, Esophagus CancerIntervention · Ivonescimab, 5-FluorouracilUpdated Mar 2026
NCT06953999PHASE3RECRUITING

A Phase III Study of Ivonescimab + Chemo With/Without AK117 in Metastatic Pancreatic Cancer

Sponsor · AkesoCondition · Pancreatic CancerIntervention · Ivonescimab, AK117, Albumin-bound Paclitaxel, Gemcitabine, Ivonescimab, AK117 Placebo, Albumin-bound Paclitaxel, GemcitabineUpdated Mar 2026
NCT06672575PHASE1, PHASE2RECRUITING

A Phase I/II Study of IVONESCIMAB in Recurrent Glioblastoma

Sponsor · M.D. Anderson Cancer CenterCondition · GlioblastomaIntervention · IvonescimabUpdated Feb 2026
NCT06767514PHASE3RECRUITING

Clinical Study of Ivonescimab for First-line Treatment of Metastatic NSCLC Patients With High PD-L1

Sponsor · Summit TherapeuticsCondition · Non-Small Cell Lung CancerIntervention · Ivonescimab Injection, Pembrolizumab InjectionUpdated Feb 2026
NCT07405190PHASE2NOT_YET_RECRUITING

Ivonescimab Alone And With Carboplatin/Pemetrexed For NSCLC

Sponsor · Massachusetts General HospitalCondition · Lung Cancer (NSCLC), Lung Cancer Non-Small Cell Cancer (NSCLC)Intervention · Ivonescimab, carboplatinUpdated Feb 2026
NCT07374250PHASE2NOT_YET_RECRUITING

Perioperative Ivonescimab Plus S-1 and Oxaliplatin (SOX) for Locally Advanced Gastric or GEJ Adenocarcinoma

Sponsor · Sichuan UniversityCondition · Gastric Cancer, RCTIntervention · Ivonescimab (20mg/kg Q3W), OxaliplatinUpdated Jan 2026
NCT07339839PHASE1, PHASE2NOT_YET_RECRUITING

Glecirasib Combined With Ivonescimab for First-line Treatment of KRAS G12C-mutated NSCLC

Sponsor · Cancer Institute and Hospital, Chinese Academy of Medical SciencesCondition · NSCLC Stage IV, KRAS G12CIntervention · Glecirasib, IvonescimabUpdated Jan 2026
NCT07094685PHASE2RECRUITING

Ivonescimab Before Surgery for the Treatment of Resectable Stage II-IV Head and Neck Cancer

Sponsor · University of Michigan Rogel Cancer CenterCondition · Advanced Head and Neck Squamous Cell Carcinoma, Resectable Head and Neck Squamous Cell CarcinomaIntervention · Biopsy Procedure, Biospecimen CollectionUpdated Nov 2025
NCT07244965PHASE2NOT_YET_RECRUITING

Neoadjuvant Ivonescimab Plus Chemotherapy Followed by Concurrent Chemoradiotherapy in High-Risk Locally Advanced Cervical Cancer

Sponsor · Women's Hospital School Of Medicine Zhejiang UniversityCondition · LOCALLY ADVANCED CERVICAL CANCERSIntervention · Ivonescimab Combined With Chemotherapy, CONCURRENT CHEMORADIATION (CISPLATIN)Updated Nov 2025
NCT07245446PHASE2RECRUITING

A Study of Ivonescimab in First-Line ES-SCLC

Sponsor · AkesoCondition · Extensive-stage Small Cell Lung Cancer (ES-SCLC)Intervention · Ivonescimab, CadonilimabUpdated Nov 2025
NCT07241819PHASE2NOT_YET_RECRUITING

Ivonescimab Monotherapy or in Combination With Chemotherapy as Neoadjuvant/Adjuvant Therapy for Resectable Non-small Cell Lung Cancer

Sponsor · Peking University Cancer Hospital & InstituteCondition · II-IIIB (T3N2) Resectable Non-small Cell Lung Cancer, PerioperativeIntervention · Ivonescimab/surgery, Ivonescimab/chemotherapy/surgeryUpdated Nov 2025
NCT07234877PHASE2NOT_YET_RECRUITING

A Randomized Phase II Study Evaluating Upfront SRT to All Brain Metastases Followed by Ivonescimab Plus Chemotherapy Versus Upfront Ivonescimab Plus Chemotherapy in Patients With Asymptomatic Active Brain Metastases From NSCLC

Sponsor · European Organisation for Research and Treatment of Cancer - EORTCCondition · Non Small Cell Lung CancerIntervention · ivonescimabUpdated Nov 2025
NCT07208773PHASE1, PHASE2RECRUITING

A Study of YL201 and Ivonescimab (AK112) in Advanced Solid Tumors

Sponsor · MediLink Therapeutics (Suzhou) Co., Ltd.Condition · Advanced Solid Tumors, Non Small Cell Lung CancerIntervention · YL201, IvonescimabUpdated Nov 2025
NCT07229417PHASE2RECRUITING

IvoLoC Trial: A Phase II Trial Evaluating the Efficacy of Ivonescimab in Metastatic Endocrine Refractory HR-positive HER2-negative or Triple Negative Invasive Lobular Carcinoma

Sponsor · M.D. Anderson Cancer CenterCondition · Metastatic Endocrine Refractory, Triple Negative Invasive Lobular CarcinomaIntervention · IvonescimabUpdated Nov 2025
NCT06980077PHASE2RECRUITING

Ivonescimab for the Treatment of Thymic Cancer

Sponsor · Jonsson Comprehensive Cancer CenterCondition · Thymus CarcinomaIntervention · Biopsy Procedure, Biospecimen CollectionUpdated Oct 2025
NCT06848842PHASE2RECRUITING

Ivonescimab Plus Chemotherapy in Patients With Initially Unresectable Colorectal Cancer Liver Metastases

Sponsor · Cancer Institute and Hospital, Chinese Academy of Medical SciencesCondition · Colorectal Liver MetastasesIntervention · Ivonescimab plus chemotherapyUpdated Oct 2025
NCT07188103PHASE2RECRUITING

Ivonescimab Plus Short-Course Hypofractionated Radiotherapy as Second-Line Therapy for Esophageal Squamous Cell Carcinoma

Sponsor · Anhui Provincial HospitalCondition · Esophageal Squamous Cell CarcinomaIntervention · Ivonescimab+RadiotherapyUpdated Sep 2025
NCT07095803PHASE2NOT_YET_RECRUITING

Ivonescimab (PD-1/VEGF Bispecific Antibody) Plus Radiofrequency Ablation for Multiple Advanced Tumors After PD-1 Therapy Failure

Sponsor · Sheng ZhangCondition · Multiple Advanced Tumors After PD-1 Therapy FailureIntervention · Ivonescimab (20mg/kg Q3W), radiofrequency ablationUpdated Jul 2025
NCT06805617PHASE2RECRUITING

A Phase 2 Trial of Ivonescimab for Patients With Advanced, Metastatic Salivary Gland Cancers

Sponsor · Glenn J. HannaCondition · Salivary Gland Cancer, Advanced Salivary Gland CarcinomaIntervention · IvonescimabUpdated Jul 2025
NCT07086326PHASE2NOT_YET_RECRUITING

A Phase II Randomized Trial of Neoadjuvant Ivonescimab or Penpulimab Plus Chemotherapy in Resectable NSCLC

Sponsor · Yang Fan, MDCondition · NSCLC, Neoadjuvant TherapyIntervention · Ivonescimab+Chemo, Penpulimab+ChemoUpdated Jul 2025
NCT07064902PHASE2NOT_YET_RECRUITING

Ivonescimab Combined With Chemoradiotherapy in High-Risk Locoregionally Advanced Nasopharyngeal Carcinoma

Sponsor · Sun Yat-sen UniversityCondition · Nasopharyngeal Carcinoma (NPC)Intervention · Ivonescimab(AK112,a PD-1/VEGF bispecific antibody)Updated Jul 2025
NCT07009925PHASE2NOT_YET_RECRUITING

Phase II Study of Platinum (Cisplatin/Carboplatin)and Polymeric Micelles Paclitaxel(Pm-Pac) With Ivonescimab in First Line Metastatic Squamous NSCLC.

Sponsor · Jiangsu Cancer Institute & HospitalCondition · Squamous Cell Lung CancerIntervention · Ivonescimab 20mg/kg intravenous every 3 weeksUpdated Jun 2025
NCT06991491PHASE2NOT_YET_RECRUITING

Ivonescimab With GnP and SBRT in Patients With Metastatic Pancreatic Cancer (WGOG-PAN 004)

Sponsor · West China HospitalCondition · Pancreatic CancerIntervention · GnP in combination with Ivonescimab and SBRTUpdated May 2025
NCT06993025PHASE2NOT_YET_RECRUITING

Ivonescimab in Combination With Liposomal Irinotecan and 5-FU/LV in Potentially Resectable Biliary Tract Malignancies

Sponsor · Tianjin Medical University Cancer Institute and HospitalCondition · Biliary Tract CancerIntervention · Ivonescimab+chemotherapyUpdated May 2025
NCT06977542PHASE2NOT_YET_RECRUITING

Neoadjuvant Therapy With Ivonescimab Combined With Chemotherapy for Triple-Negative Breast Cancer

Sponsor · Fudan UniversityCondition · TNBC, Triple Negative Breast CancerIntervention · IvonescimabUpdated May 2025
NCT06957561PHASE1, PHASE2NOT_YET_RECRUITING

Disitamab Vedotin Combined With Ivonescimab in Cisplatin-Ineligible Muscle-Invasive Bladder Cancer

Sponsor · Sun Yat-sen UniversityCondition · Bladder Cancer, Muscle-invasive Bladder CancerIntervention · Disitamab Vedotin Injection, Ivonescimab(AK112,a PD-1/VEGF bispecific antibody)Updated May 2025
NCT06790212PHASE2NOT_YET_RECRUITING

Neoadjuvant CAPOX Plus Ivonescimab Versus CAPOX for Locally Advanced Colon Cancer

Sponsor · Sun Yat-sen UniversityCondition · Colon CancerIntervention · Ivonescimab, OxaliplatinUpdated Mar 2025
NCT06875076PHASE2RECRUITING

Multicenter Single-Arm Study of Ivonescimab (AK112) Combined with Chemotherapy in Pretreated Pleural Mesothelioma

Sponsor · The First Hospital of Jilin UniversityCondition · Pretreated Pleural MesotheliomaIntervention · Ivonescimab Combined With ChemotherapyUpdated Mar 2025
NCT06820762PHASE2NOT_YET_RECRUITING

Irinotecan Liposome(II) Combined With Ivonescimab as Second-line Treatment for Small Cell Lung Cancer : A Prospective, Single-arm, Multicenter Clinical Study

Sponsor · The Second Affiliated Hospital of Dalian Medical UniversityCondition · SCLCIntervention · irinotecan liposome(II) plus Ivonescimab via intravenously (IV) Q3W for 4-6 cycles, followed by Ivonescimab until disease progression or intolerable toxicityUpdated Feb 2025
NCT06814067PHASE2NOT_YET_RECRUITING

Phase II Multi-centered Study of Perioperative Ivonescimab Versus Pembrolizumab Combined with Standard of Care (SOC) in Patients with Resectable, Locally Advanced Head and Neck Squamous Cell Carcinoma

Sponsor · Fudan UniversityCondition · Head and Neck Squamous Cell Carcinoma, Head and Neck Squamous Cell Carcinoma HNSCCIntervention · Pembrolizumab, IvonescimabUpdated Feb 2025
NCT06814158PHASE2NOT_YET_RECRUITING

Neoadjuvant Ivonescimab and Chemotherapy in Resectable Esophageal Cancer

Sponsor · Tianjin Medical University Cancer Institute and HospitalCondition · Esophageal Squamour Cell CancerIntervention · Ivonescimab Combined With ChemotherapyUpdated Feb 2025
NCT06793332PHASE2RECRUITING

BrAin Metastasis in tripLe Negateive Breast Cancer: IvoneScimab and Trop2 ADC

Sponsor · Fudan UniversityCondition · Triple-Negative Breast Cancer (TNBC), Brain MetastasesIntervention · Ivonescimab Combined With TROP2 ADCUpdated Jan 2025
NCT07038915PHASE2WITHDRAWN

STRIVE: A Single-arm Phase 2 Study on Treatment of Lung Squamous Cell Carcinoma by Tiragolumab Plus Ivonescimab for Patients Who Progressed on Platinum Doublets and Anti-PD-1/PD-L1

Sponsor · M.D. Anderson Cancer CenterCondition · Lung Squamous Cell Carcinoma, Anti-PD1/PDL1 AntibodyIntervention · Tiragolumab, IvonescimabUpdated Aug 2025
NCT06936488NAENROLLING_BY_INVITATION

A Prospective, Single Arm, Open Label, Phase II Clinical Study on the Efficacy and Safety of Ivonescimab (AK112) Combined With TAS-102 in the Treatment of Refractory MSS/pMMR Advanced Colorectal Cancer

Sponsor · Huai'an First People's HospitalCondition · MSS/pMMR Type Metastatic Colorectal Adenocarcinoma PatientsIntervention · Ivonescimab,TAS-102Updated Apr 2025
NCT07385001PHASE1, PHASE2RECRUITING

A Prospective, Multicenter, Phase Ib/II Trial of Ivonescimab (AK112) Combined With Albumin-Paclitaxel and Cisplatin as Neoadjuvant Therapy for ESCC

Sponsor · Tang-Du HospitalCondition · Esophageal Squamous Cell Carcinoma, IvonescimabIntervention · AK112, AK112Updated Feb 2026
NCT07603791PHASE2NOT_YET_RECRUITING

Phase II Clinical Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Antitumor Activity of ALK202 for Injection in Combination With Drugs in NSCLC Participants.

Sponsor · Shanghai Allink Biotherapeutics Co., Ltd.Condition · NSCLC (Advanced Non-small Cell Lung Cancer)Intervention · ALK202 for injection, Osimertinib Mesylate TabletsUpdated May 2026
NCT06868732PHASE1RECRUITING

Evaluation of JSKN016 Combination Therapy in Subjects With NSCLC

Sponsor · Jiangsu Alphamab Biopharmaceuticals Co., LtdCondition · Advanced Non-small Cell Lung CancerIntervention · JSKN016, CarboplatinUpdated Mar 2026
NCT05184712PHASE3ACTIVE_NOT_RECRUITING

Phase 3 Clinical Study of AK112 for NSCLC Patients

Sponsor · AkesoCondition · Non-Squamous Non-small Cell Lung CancerIntervention · Ivonescimab (SMT112 or AK112) Injection, Placebo InjectionUpdated Mar 2026
NCT07393555PHASE2NOT_YET_RECRUITING

Treatment for Advanced Non-small Cell Lung Cancer With Actionable Genomic Alterations After Targeted Treatment and Chemotherapy (An Expanded Lung-MAP Treatment Trial)

Sponsor · SWOG Cancer Research NetworkCondition · Recurrent Lung Non-Small Cell Carcinoma, Stage IV Lung Cancer AJCC v8Intervention · Biospecimen Collection, Computed TomographyUpdated Feb 2026
NCT07394218PHASE2RECRUITING

ctDNA-guided Treatment Decision-making

Sponsor · Fudan UniversityCondition · Metastatic Breast Cancer ( HER2 Negative), ctDNAIntervention · ADC, IvonescimabUpdated Feb 2026
NCT07381075PHASE2NOT_YET_RECRUITING

A Phase II Clinical Trial of Anti-EGFR Antibody-drug Conjugate (ADC) Combined With or Without Immune Checkpoint Inhibitors in the Neoadjuvant Treatment of Resectable Locally Advanced Head and Neck Squamous Cell Carcinoma

Sponsor · West China HospitalCondition · Head and Neck Squamous Cell CarcinomaIntervention · Becotatug Vedotin, Becotatug Vedotin Combined with PenpulimabUpdated Feb 2026
NCT06877650PHASE1, PHASE2RECRUITING

First-in-Human Investigation of JMT108 Injection in Participants With Advanced Malignant Tumors

Sponsor · Shanghai JMT-Bio Inc.Condition · Advanced Malignant TumorsIntervention · JMT108, PembrolizumabUpdated Jan 2026
NCT07204548PHASE2NOT_YET_RECRUITING

The IVO-LUNG Study

Sponsor · Sun Yat-sen UniversityCondition · Non Small Cell Lung Cancer (Stage III)Intervention · IvonescimabUpdated Oct 2025
NCT07070479PHASE2RECRUITING

Combination Therapy for PD-1 Resistant Recurrent or Metastatic Nasopharyngeal Carcinoma: A Bayesian Adaptive Phase II Trial

Sponsor · Ming-Yuan ChenCondition · Recurrent or Metastatic Nasopharyngeal CarcinomaIntervention · Ivonescimab, NimotuzumabUpdated Sep 2025
NCT07162714PHASE2NOT_YET_RECRUITING

SCRT Followed by AK112 in pMMR/MSS Mid-low Rectal Cancer

Sponsor · Zhejiang Cancer HospitalCondition · Rectal Cancer, RadiationIntervention · radiotherapy, Ivonescimab (20mg/kg Q3W)Updated Sep 2025
NCT06913218PHASE1NOT_YET_RECRUITING

A Study of mRNA Vaccines AK154 Monotherapy or in Combination With AK104/AK112,and Sequential mFOLFIRINOX in Surgically Resected PDAC

Sponsor · AkesoCondition · Pancreas Cancer, Pancreas Cancer, Duct Cell AdenocarcinomaIntervention · AK154, CadonilimabUpdated Apr 2025
NCT06802666PHASE2RECRUITING

Short-course Radiotherapy Followed by AK112 and CAPOX as Neoadjuvant Therapy for Locally Advanced Rectal Cancer

Sponsor · Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyCondition · Locally Advanced Rectal Cancer, Neoadjuvant TherapyIntervention · short-course radiotherapy, IvonescimabUpdated Jan 2025
NCT07440212NOT_YET_RECRUITING

Clinical Study on Noninvasive Evaluation of Ivonescimab Antibody Distribution and Expression in Esophageal Cancer Patients by 89Zr-AK112 PET Imaging

Sponsor · Daping Hospital and the Research Institute of Surgery of the Third Military Medical UniversityCondition · Esophagus CancerUpdated Feb 2026
NCT07363408PHASE1NOT_YET_RECRUITING

Ivonescimab and ADG126, Alone, and in Combination With Leucovorin and Fluorouracil or FOLFIRI Regimen for the Treatment of Microsatellite Stable Advanced/Metastatic Colorectal Cancer

Sponsor · City of Hope Medical CenterCondition · Advanced Microsatellite Stable Colorectal Carcinoma, Metastatic Microsatellite Stable Colorectal CarcinomaIntervention · Biospecimen Collection, Computed TomographyUpdated Jan 2026
NCT07226544PHASE2NOT_YET_RECRUITING

Ivonescimab Prior to Surgery for the Treatment of High-Risk Localized Clear Cell Renal Cell Cancer

Sponsor · City of Hope Medical CenterCondition · Localized Clear Cell Renal Cell Carcinoma, Resectable Clear Cell Renal Cell CarcinomaIntervention · Biopsy Procedure, Biospecimen CollectionUpdated Nov 2025
NCT06683846PHASE2RECRUITING

Ivonescimab in the Treatment of Multiple Advanced Tumors

Sponsor · Fudan UniversityCondition · Pheochromocytoma/Paraganglioma, RhabdomyosarcomaIntervention · IvocizumabUpdated Aug 2025
NCT07130240PHASE2RECRUITING

Ivonescimab Combined With Paclitaxel and Cisplatin as Neoadjuvant Therapy Followed by Type A Hysterectomy in Stage IB2 and IIA1 Cervical Cancer

Sponsor · Obstetrics & Gynecology Hospital of Fudan UniversityCondition · Cervical CancersIntervention · Neoadjuvant Chemotherapy Combined with ImmunotherapyUpdated Aug 2025
NCT06904300PHASE2NOT_YET_RECRUITING

Ivonescimab (AK112) Plus Paclitaxel as Second-line Therapy in Patients With Advanced G/GEJ Cancer

Sponsor · Sun Yat-sen UniversityCondition · Gastric (Cardia, Body) CancerIntervention · AK112 + paclitaxel, Paclitaxel ± ramucirumabUpdated Jun 2025
NCT06944106PHASE2RECRUITING

A Study on Ivonescimab Plus Chemotherapy as Neoadjuvant Therapy for Borderline Resectable Pancreatic Cancer

Sponsor · Tianjin Medical University Cancer Institute and HospitalCondition · Pancreatic CancerIntervention · AK112Updated May 2025
NCT06990620PHASE1NOT_YET_RECRUITING

TACE Plus Ivonescimab for Unresectable Non-Metastatic HCC

Sponsor · Fudan UniversityCondition · Hepatocellular Carcinoma (HCC)Intervention · TACE+AK112Updated May 2025
NCT06936644PHASE2NOT_YET_RECRUITING

A Multicenter, Single-arm Phase II Study to Evaluate the Efficacy and Safety of Fulzerasib (IBI351) in Combination With Ivonescimab (AK-112) in First-line Treatment of Advanced or Metastatic Non-small Cell Lung Cancer Patients With KRAS G12C Mutation

Sponsor · Shanghai Chest HospitalCondition · KRAS G12C Lung CancerIntervention · IBI351+AK112Updated Apr 2025
NCT06919510PHASE2NOT_YET_RECRUITING

A Phase ll Study of Neoadjuvant Short-course Radiotherapy Followed by Ivonescimab and Chemotherapy in pMMR/MSS Locally Advanced Rectal Cancer

Sponsor · Sun Yat-sen UniversityCondition · Rectal AdenocarcinomaIntervention · lvonescimab, CAPOX (oxaliplatin/capecitabine)Updated Apr 2025
NCT07021950PHASE2NOT_YET_RECRUITING

AK112 Plus FOLFIRI Versus Bevacizumab Plus FOLFIRI as Second-line Treatment of MSS/pMMR Metastatic Colorectal Cancer

Sponsor · Sun Yat-sen UniversityCondition · Colorectal Cancer, IvonescimabIntervention · AK112, FOLFIRIUpdated Jun 2025
NCT05582499PHASE2RECRUITING

Fudan University Shanghai Cancer Center Breast Cancer Precision Platform Series Study- Neoadjuvant Therapy

Sponsor · Fudan UniversityCondition · Breast Neoplasm, Breast CancerIntervention · Dalpiciclib, PyrotinibUpdated May 2026
NCT01042379PHASE2RECRUITING

I-SPY TRIAL: Neoadjuvant and Personalized Adaptive Novel Agents to Treat Breast Cancer

Sponsor · QuantumLeap Healthcare CollaborativeCondition · Breast Neoplasms, Breast CancerIntervention · Standard Therapy, AMG 386 with or without TrastuzumabUpdated May 2026
NCT06145308PHASE2RECRUITING

Precision Treatment of Recurrent/Metastatic Salivary Gland Carcinoma Guided by Molecular Typing

Sponsor · Peking Union Medical CollegeCondition · Salivary Gland Carcinoma, Precision TherapyIntervention · Cohort 1 (HER2-positive, RC48-ADC), Cohort 2 (NTRK-fusion or NTRK-mutant)Updated Apr 2026
NCT06396065PHASE3ACTIVE_NOT_RECRUITING

Phase III Study of AK112 for NSCLC Patients

Sponsor · Summit TherapeuticsCondition · Non-Squamous Non-small Cell Lung CancerIntervention · AK112 Injection, Placebo InjectionUpdated Mar 2026
NCT07489703PHASE2NOT_YET_RECRUITING

SHR-A1811 + AK112 in HER2-Altered Advanced/Metastatic NSCLC

Sponsor · Sun Yat-sen UniversityCondition · Non-Small Cell Lung CancerIntervention · SHR-A1811 plus AK112Updated Mar 2026
NCT07010263PHASE3RECRUITING

A Study of AK112 as Consolidation Treatment for Patients With Limited Stage Small-cell Lung Cancer Who Have Not Progressed Following Concurrent Chemoradiation Therapy

Sponsor · AkesoCondition · Small Cell Lung CancerIntervention · AK112, PlaceboUpdated Mar 2026
NCT06928922EARLY_PHASE1RECRUITING

Inhaled mRNA Tumor-associated Antigen Dry Powder Vaccine in Advanced Lung Cancer and Lung Metastasis of Solid Tumors.

Sponsor · Cancer Institute and Hospital, Chinese Academy of Medical SciencesCondition · Advanced Lung Cancer, Lung MetastasisIntervention · BMD006 monotreatment, BMD006 in combination with PD-1 antibodyUpdated Jan 2026
NCT07076693PHASE2, PHASE3ACTIVE_NOT_RECRUITING

Standard-of-care Systemic Therapy With or Without Local Therapy in Patients With Oligoprogressive Non-Small Cell Lung Cancer(NSCLC)

Sponsor · Shanghai Chest HospitalCondition · OligoProgressive Metastatic Disease, Non-Small Cell Lung CancerIntervention · Radiotherapy or Surgery, Standard Medical TherapyUpdated Jul 2025
NCT06402435PHASE2RECRUITING

SBRT, Chemotherapy, and AK112 Neoadjuvant Therapy for Luminal-type Breast Cancer

Sponsor · Hubei Cancer HospitalCondition · Breast CancerIntervention · Lvonescimab (AK112)Updated Jul 2025
NCT06686030PHASE2RECRUITING

Combination Therapy of AK112 With Chemotherapy and/or Olaparib in Platinum-sensitive Ovarian Cancer

Sponsor · AkesoCondition · Platinum-sensitive Ovarian CancerIntervention · AK112 low dose, ChemotherapyUpdated Apr 2025
NCT06718543PHASE2RECRUITING

Neoadjuvant Short-Course Radiotherapy With or Without Chemotherapy and AK112 in Locally Advanced Rectal Cancer

Sponsor · fan liCondition · Rectal CancerIntervention · AK112 with SCRT and CapeOX, AK112 with SCRTUpdated Apr 2025
NCT06560112PHASE2RECRUITING

An Exploratory, Multi-cohort Phase II Study of Combination Therapy With AK104 and AK112 for Recurrent Ovarian Cancer

Sponsor · AkesoCondition · Recurrent Ovarian CancerIntervention · AK104, AK112Updated Mar 2025
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